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Diphosphonate therapy of paget's disease of bone.

Author: BohneW, CanfieldR, FeldmanF, KammermanS, KunigonisM, McWhorterJ, ResnickL, RosnerW, RyanK, SkinnerJ

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

A study of 75 patients with Paget's disease of bone found that EHDP therapy was effective in reducing urinary hydroxyproline and serum alkaline phosphatase levels. However, patients receiving higher doses of EHDP (10 or 20 mg/kg/day) had less favorable outcomes than those receiving lower doses (2.5 or 5 mg/kg/day).
Paper Details　
Original Abstract of the Article :
The use of disodium ethane-1 hydroxy-1, 1-diphosphonate (EHDP) therapy for Paget's disease of bone was examined in 75 affected patients. Forty-eight patients received randomly assigned oral doses of either 0, 2.5, 5, 10, or 20 mg/kg/day in a controlled, double-blind protocol, and the remainder recei...See full text at original site
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引用元：
https://doi.org/10.1210/jcem-44-1-96

データ提供：米国国立医学図書館（NLM）

Diphosphonate Therapy for Paget's Disease of Bone: Optimizing Treatment Efficacy

Paget's disease of bone, a chronic condition characterized by abnormal bone remodeling, often requires treatment with diphosphonates. This study investigates the efficacy of disodium ethane-1 hydroxy-1, 1-diphosphonate (EHDP) therapy in patients with Paget's disease. Researchers conducted a controlled, double-blind study, assigning patients to receive different doses of EHDP or placebo. They evaluated the clinical status, urinary hydroxyproline levels, and serum alkaline phosphatase levels before and during treatment.

Optimizing EHDP Dosage for Maximum Benefit and Minimized Risk

The study found that EHDP therapy effectively reduced both urinary hydroxyproline and serum alkaline phosphatase levels, suggesting a beneficial effect on bone remodeling. However, patients receiving the higher doses of EHDP (10 or 20 mg/kg/day) had less favorable outcomes compared to those receiving lower doses (2.5 or 5 mg/kg/day). The higher dose group experienced a lower rate of symptom improvement and a higher rate of deterioration. Based on these findings, the researchers recommend an initial EHDP dose of 5 mg/kg/day to maximize benefits while minimizing potential adverse effects.

The Importance of Personalized Treatment for Paget's Disease

This research highlights the importance of individualized treatment strategies for Paget's disease, emphasizing the need for careful dose optimization to maximize benefits and minimize potential risks. Further studies are needed to investigate the long-term efficacy and safety of diphosphonate therapy in managing this chronic condition.

Dr.Camel's Conclusion

This research is like a camel caravan traversing a desert of bone, searching for the optimal treatment for Paget’s disease. It explores the efficacy of EHDP therapy and underscores the importance of personalized dosing to maximize benefits. It’s like discovering a hidden oasis in the desert – a reminder that careful planning and attention to detail are crucial for a successful journey.

Date :
  1. Date Completed 1977-03-21
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

401827

DOI: Digital Object Identifier

10.1210/jcem-44-1-96

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・Effective treatment of paget's disease of bone
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PICO Info
in preparation
Languages

English

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