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Comparative efficacy and safety of short-acting and sustained release quinidine in the treatment of patients with ventricular arrhythmias.

Author: HunterH, MorganrothJ

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A once-a-day quinidine preparation, Quiniday, was as effective and safe as other forms of quinidine in 76 patients with ventricular premature complexes, despite its once-a-day dosing schedule.
Paper Details　
Original Abstract of the Article :
A comparative, fixed-dose, parallel, randomized, blinded trial to define the efficacy and safety of a new once-a-day quinidine preparation, Quiniday, at 1200 mg per day, was compared to quinidine sulfate (as Quinora, 300 mg four times daily, and Quinidex Extentabs, 600 mg twice daily) and to quinidi...See full text at original site
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引用元：
https://doi.org/10.1016/0002-8703(85)90008-0

データ提供：米国国立医学図書館（NLM）

Quinidine: A Versatile Antiarrhythmic Agent, Regardless of Formulation

Ventricular arrhythmias, irregular heartbeats originating in the lower chambers of the heart, can be a serious health concern. Quinidine, a well-established antiarrhythmic medication, is available in various formulations, each with its own dosing schedule. This research compared the efficacy and safety of different quinidine preparations in treating patients with ventricular arrhythmias.

Different Quinidine Formulations: Similar Efficacy and Safety

The study involved 76 patients with frequent ventricular premature complexes (VPCs). Participants were randomly assigned to receive one of four quinidine preparations: Quiniday (once-a-day), Quinora (four times daily), Quinidex Extentabs (twice daily), and Quinaglute Dura-Tabs (twice daily). The results showed no significant difference in efficacy or safety between the different preparations. This suggests that the choice of formulation may be guided by factors such as dosing convenience and individual patient preferences.

Quinidine: A Reliable Option for Managing Ventricular Arrhythmias

The findings reinforce the reliability of quinidine as an effective antiarrhythmic agent. The study demonstrates that the different formulations, despite their varying dosing schedules, provide comparable efficacy and safety. This research emphasizes the importance of patient compliance with medication regimens, particularly for individuals with potentially life-threatening conditions such as ventricular arrhythmias.

Dr.Camel's Conclusion

Just as a camel can navigate diverse terrains, quinidine, in its various formulations, proves to be a versatile and effective treatment for ventricular arrhythmias. The choice of formulation can be tailored to individual needs and preferences, offering a customizable approach to managing this critical health concern. However, always consult with a healthcare professional to determine the most appropriate treatment strategy for your specific condition.

Date :
  1. Date Completed 1985-12-31
  2. Date Revised 2019-06-26
Further Info :

Pubmed ID

4072874

DOI: Digital Object Identifier

10.1016/0002-8703(85)90008-0

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Languages

English

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