Improved survival of increased-risk myeloma patients on combined triple-alkylating-agent therapy: a study of the CALGB.

Author: ColemanM, CooperM R, CuttnerJ, HarleyJ B, KochwaS, McIntyreO R, PajakT F

Paper Details 
Original Abstract of the Article :
Two hundred fifty-two previously untreated evaluable patients with multiple myeloma were entered into a study testing a regimen of three intravenous alkylating agents, melphalan, cyclophosphamide, and carmustine (BCNU), given in combination (BCMP) against a regimen employing oral melphalan (MP). Bot...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/444661

データ提供:米国国立医学図書館(NLM)

Combined Triple-Alkylating-Agent Therapy: A New Oasis in the Desert of Multiple Myeloma Treatment

The quest for effective treatments for multiple myeloma is a challenging and often arduous journey, much like traversing a vast and unforgiving desert landscape. This research focuses on the use of combined triple-alkylating-agent therapy, a powerful combination of medications, as a potential treatment option for this complex disease. It's like discovering a new oasis in the desert of multiple myeloma treatment, offering hope for a more effective and less burdensome approach to managing this disease.

The study compared the outcomes of two treatment regimens: one involving a combination of three alkylating agents (BCMP) and another involving oral melphalan (MP). The authors found that BCMP therapy resulted in significantly more frequent objective responses and improved survival for patients with high tumor cell load (poor-risk group). It's like finding a new, more resilient species of camel that can thrive in the harshest desert environments, offering a better chance of survival in the face of this challenging disease.

Combined Triple-Alkylating-Agent Therapy: A Promising Strategy for Poor-Risk Patients

The study's findings suggest that combined triple-alkylating-agent therapy may offer a promising strategy for poor-risk multiple myeloma patients, potentially improving their survival rates and quality of life. It's like finding a new, more effective route through the desert of multiple myeloma treatment, leading to a brighter and more hopeful future for these patients.

Navigating the Desert of Multiple Myeloma Treatment: A Journey of Precision

While this research is promising, it's important to remember that the optimal treatment for multiple myeloma may depend on the individual patient's characteristics and the stage of their disease. It's like navigating a vast desert – one must carefully assess the terrain and choose the most appropriate path for each journey. Further research is needed to optimize the use of combined triple-alkylating-agent therapy and explore other potential treatments, ensuring that we're always navigating toward the best possible outcomes for patients.

Dr. Camel's Conclusion

This research offers a glimmer of hope in the desert of multiple myeloma treatment. Combined triple-alkylating-agent therapy shows promise as a potentially more effective strategy for poor-risk patients, offering a brighter outlook for those affected by this challenging disease. It's a journey of discovery, as we continue to seek new and innovative ways to combat the challenges of multiple myeloma.

Date :
  1. Date Completed 1979-08-16
  2. Date Revised 2021-02-16
Further Info :

Pubmed ID

444661

DOI: Digital Object Identifier

S0006-4971(20)72623-6

Related Literature

SNS
PICO Info
in preparation
Languages

English

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