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Comparative effects of ticrynafen and hydrochlorothiazide on blood pressure, renal function, serum uric acid and electrolytes, and body fluid spaces in hypertensive man.

Author: BauerJ H, BrooksC S

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Ticrynafen and hydrochlorothiazide both effectively lowered blood pressure and caused similar electrolyte disturbances. Ticrynafen lowered serum uric acid, while hydrochlorothiazide increased it.
Paper Details　
Original Abstract of the Article :
25 hypertensive subjects underwent a double-blind, randomized study to compare the effects of ticrynafen (TCNF) with hydrochlorothiazide (HCTZ) on blood pressure (BP), renal function, serum uric acid (UA) and electrolytes, and body fluid spaces. BP was similarly lowered by TCNF and HCTZ. Neither TCN...See full text at original site
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引用元：
https://doi.org/10.1159/000181670

データ提供：米国国立医学図書館（NLM）

Ticrynafen vs. Hydrochlorothiazide: A Comparative Study

The desert of [hypertension] is a treacherous landscape, requiring careful navigation to manage this prevalent condition. This study delves into the comparative effects of two diuretics, [ticrynafen] and [hydrochlorothiazide], on blood pressure, renal function, and other relevant parameters.

A Double-Blind, Randomized Study: Comparing Diuretic Effects

The researchers conducted a double-blind, randomized study to compare the efficacy and side effects of ticrynafen and hydrochlorothiazide in a group of hypertensive individuals.

Navigating the Desert of Hypertension Treatment

This study provides valuable insights into the effects of two commonly used diuretics in the management of hypertension. The findings highlight the potential advantages and disadvantages of each drug, offering guidance for clinicians in selecting appropriate treatment options.

Dr.Camel's Conclusion

In the desert of hypertension, we must carefully select our tools to effectively combat this formidable foe. This study provides a valuable comparison of two diuretics, ticrynafen and hydrochlorothiazide, offering a roadmap for clinicians in navigating the diverse treatment options available. As we continue our quest for optimal hypertension management, it is crucial to remain informed about the latest research and the potential benefits and risks of various therapeutic approaches.
Date :
  1. Date Completed 1979-10-24
  2. Date Revised 2018-02-15
Further Info :

Pubmed ID

471153

DOI: Digital Object Identifier

10.1159/000181670

Related Literature

Article Analysis
・Effects of hydrochlorothiazide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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