Comparative study of cardiovascular, neurological and metabolic side effects of 8 narcotics in dogs. Pethidine, piritramide, morphine, phenoperidine, fentanyl, R 39 209, sufentanil, R 34 995. II. Comparative study on the epileptoid activity of the narcotics used in high and massive doses in curarised and mechanically ventilated dogs.

Author: KayB, RenemanR, Van de WaterA, WoutersL, XhonneuxR, de CastroJ

Overview

The convulsion threshold for various narcotics was determined in dogs. The safety margin for neurological toxicity was inversely related to analgesic potency, with stronger analgesics having lower margins.

Paper Details　

Original Abstract of the Article :

The experimental design, described in part I, was again used here. The electrocortical activity was registered with an EEG amplifier using a bipolar derivation of needle electrodes fixed in the scalp of a dog in the fronto-occipital position. In this situation the convlusion threshold for the 8 subs...See full text at original site

Dr.Camel's Paper Summary Blog

Navigating the Desert of Narcotic Toxicity: A Comparative Study

The quest for safe and effective pain relief is an ongoing journey in the field of veterinary medicine. This study delves into the complex world of narcotics, examining the cardiovascular, neurological, and metabolic side effects of eight different narcotics in dogs. The researchers meticulously compare the effects of these drugs, much like charting the different routes through a vast desert landscape, to understand their potential risks and benefits.

The Sandstorm of Neurological Toxicity: A Cautionary Tale

The study highlights the neurological toxicity of narcotics, particularly their potential to induce seizures. The researchers find that different narcotics have varying levels of epileptoid activity, with some exhibiting a higher propensity for inducing seizures. This is like navigating a desert during a sandstorm, where some paths are more treacherous than others. The study emphasizes the importance of carefully selecting the appropriate narcotic and monitoring patients closely for signs of neurological toxicity.

Navigating the Desert of Pain Management: A Guide for Veterinarians

This study provides valuable insights into the complex world of narcotic use in veterinary medicine. It underscores the importance of carefully weighing the potential benefits and risks of different narcotics, taking into account the individual patient's health status and potential drug interactions. It's like a wise desert guide, carefully navigating the risks and rewards of each route to ensure a safe and successful journey.

Dr.Camel's Conclusion

This study explores the complex world of narcotic use in veterinary medicine, highlighting the importance of understanding the potential risks and benefits of different drugs. It reminds us that even in the quest for pain relief, we must remain vigilant and carefully navigate the desert of potential side effects.