Paper Details

  1. Home
  2. Paper Details

Concentration effect studies with oral metoclopramide.

Author: BatemanD N, DaviesD S, KahnC

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Metoclopramide did not significantly increase gastric emptying in normal volunteers. Sedation was only observed after a 20 mg oral dose. Akathisia, a central nervous system side effect, occurred only in subjects with peak plasma concentrations above 100 ng/ml.
Paper Details　
Original Abstract of the Article :
1 The effects of single oral doses of 10 mg and 20 mg metoclopramide have been compared to placebo in six normal male volunteers. 2 The drug did not significantly increase the rate of gastric emptying as measured by ethanol absorption. 3 Sedation during the absorption of ethanol was only observed 1 ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1111/j.1365-2125.1979.tb05818.x

データ提供：米国国立医学図書館（NLM）

Metoclopramide: Navigating the Desert of Concentration-Effect Relationships

Metoclopramide is a widely used medication for gastrointestinal disorders, but its precise concentration-effect relationship remains unclear. This study investigates the effects of single oral doses of metoclopramide on gastric emptying and sedation in healthy male volunteers. The study uses a controlled design to compare the effects of different doses of metoclopramide to placebo.

The Complex Landscape of Metoclopramide: A Journey of Dose-Dependent Effects

The study reveals that metoclopramide's effects are dose-dependent. While higher doses were associated with sedation, the drug did not significantly accelerate gastric emptying. The study also identifies a correlation between peak plasma concentrations and the occurrence of akathisia, a central nervous system side effect. The findings highlight the importance of understanding the pharmacokinetics and pharmacodynamics of metoclopramide to optimize its use in clinical practice.

A Journey of Optimization: Navigating the Desert of Dosage

This study underscores the importance of understanding the dose-dependent effects of medications, particularly in the context of individualized patient care. The findings emphasize the need for careful consideration of dosage and the potential for side effects, especially when using medications like metoclopramide. Like a camel carefully navigating a desert landscape to reach a distant oasis, we must be mindful of the potential pitfalls and optimize our use of medications to achieve the best possible outcomes for our patients.

Dr. Camel's Conclusion

This research provides valuable insights into the complex landscape of metoclopramide's concentration-effect relationship. The findings highlight the importance of careful dosage considerations and individualized patient care to ensure safe and effective use of this medication. The study serves as a reminder that the journey to optimal healthcare requires a comprehensive understanding of the pharmacology of medications and a commitment to patient-centered care. Just as a camel adapts to the challenges of a desert environment, we must be adaptable and resourceful in our approach to medication management, ensuring that patients receive the best possible care.
Date :
  1. Date Completed 1979-12-27
  2. Date Revised 2019-05-09
Further Info :

Pubmed ID

486293

DOI: Digital Object Identifier

10.1111/j.1365-2125.1979.tb05818.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.