Paper Details

  1. Home
  2. Paper Details

Effects of the diuretics, triamterene and mersalyl on active sodium transport mechanisms in isolated frog skin.

Author: SalakoL A, SmithA J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Triamterene reduced sodium entry into the transporting system of frog skin, while mersalyl limited sodium exit. Both drugs affected the active sodium transport pool.
Paper Details　
Original Abstract of the Article :
1. Triamterene reduces the rate coefficients for sodium movement into the transporting system of the isolated frog skin. The isotopically measured ;active sodium transport pool' is also reduced.2. Mersalyl reduces the rate coefficient for sodium and the calculated sodium flux from the transporting s...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1111/j.1476-5381.1971.tb08053.x

データ提供：米国国立医学図書館（NLM）

Diuretics: Exploring the Mechanism of Action

The intricate world of diuretics and their impact on active sodium transport mechanisms is a fascinating area of research. This study delves into the effects of two diuretics, triamterene and mersalyl, on sodium movement in isolated frog skin. The researchers employed sophisticated techniques to measure sodium transport rates and pool sizes, revealing distinct mechanisms of action for each diuretic.

Triamterene and Mersalyl: Two Different Paths in the Desert

The study found that triamterene primarily affects the entry of sodium into the transporting system, while mersalyl hinders the exit of sodium ions from the system. This suggests that each diuretic acts at a different stage of the sodium transport process. Imagine the vast desert as a complex network of pathways, each with its unique characteristics. Triamterene and mersalyl, like two different travelers, traverse distinct routes through this desert, affecting sodium transport in different ways.

A New Perspective on Diuretic Action: Understanding the Desert Landscape

The research provides a nuanced understanding of how these diuretics influence sodium transport. This knowledge can contribute to the development of more targeted and effective diuretic therapies. By uncovering the specific mechanisms of action, we gain a deeper appreciation for the complexities of the desert landscape of sodium transport and its potential for therapeutic intervention.

Dr. Camel's Conclusion

This study offers a fascinating glimpse into the intricate world of diuretics and their effects on sodium transport. The distinct mechanisms of action revealed by this research provide valuable insights for optimizing diuretic therapies and advancing our understanding of this essential physiological process. As a researcher, I am constantly amazed by the intricate workings of the body and the potential for scientific discoveries to improve human health.

Date :
  1. Date Completed 1971-07-06
  2. Date Revised 2019-05-11
Further Info :

Pubmed ID

5576259

DOI: Digital Object Identifier

10.1111/j.1476-5381.1971.tb08053.x

Related Literature

Article Analysis
・Effects of triamterene
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.