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Tofisopam, a novel 3,4-benzodiazepine: multiple-dose effects on psychomotor skills and memory. Comparison with diazepam and interactions with ethanol.

Author: KorttilaK, MattilaM J, PalvaE, SeppäläT, ShrotriyaR C

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Diazepam impaired psychomotor skills, while tofisopam did not. Tolerance developed to diazepam's effects on reactive and coordinative skills but not on flicker fusion or extraocular muscle balance. Both drugs, when combined with alcohol, impaired psychomotor skills and may reduce the ability to drive or operate machinery.
Paper Details　
Original Abstract of the Article :
Twelve healthy male volunteers were treated (double-blind crossover design) with tofisopam (a new 3,4-benzodiazepine), diazepam, or placebo, on 2 consecutive days each. Psychomotor skills were impaired after a single dose of diazepam (10 mg) given on day 1. Measurements on day 2 showed that some tol...See full text at original site
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引用元：
https://doi.org/10.1007/BF00427652

データ提供：米国国立医学図書館（NLM）

Tofisopam: A New Benzodiazepine with Unique Properties

Benzodiazepines are a class of drugs commonly used to treat anxiety and insomnia. However, they can have side effects, such as sedation and impaired psychomotor performance. This research explores the effects of tofisopam, a new benzodiazepine, on psychomotor skills and memory, seeking to find a safer and more effective option for treating anxiety and insomnia.

The researchers conducted a double-blind, crossover study comparing the effects of tofisopam, diazepam (a traditional benzodiazepine), and placebo on psychomotor skills and memory in healthy volunteers. The researchers found that tofisopam, unlike diazepam, did not impair psychomotor performance, even after repeated doses. Furthermore, tofisopam did not significantly enhance the effects of alcohol on psychomotor skills and memory. It's like discovering a new route through the desert - tofisopam offers a potentially safer and more effective alternative to traditional benzodiazepines, without the same sedative effects.

A Potential Safer Alternative for Anxiety and Insomnia

This research offers hope for individuals seeking relief from anxiety and insomnia, highlighting the potential of tofisopam as a safer and more effective alternative to traditional benzodiazepines.

Navigating the Desert of Anxiety and Insomnia

This research provides valuable insights for individuals navigating the desert of anxiety and insomnia, offering a new and potentially safer option for treatment.

Dr. Camel's Conclusion

This research is like a journey through the desert of anxiety and insomnia, exploring the potential of tofisopam, a new benzodiazepine, as a safer and more effective treatment option. The findings suggest that tofisopam may offer a more desirable alternative to traditional benzodiazepines, minimizing sedative effects and enhancing overall well-being. It's like finding a new oasis of relief in the desert of anxiety and insomnia, offering a more comfortable and manageable journey towards better health and sleep.

Date :
  1. Date Completed 1981-03-17
  2. Date Revised 2019-07-26
Further Info :

Pubmed ID

6109345

DOI: Digital Object Identifier

10.1007/BF00427652

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Article Analysis
・Effects of diazepam
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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