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Does theophylline potentiate inhaled beta 2-agonists?

Author: SvedmyrK, SvedmyrN

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Theophylline and terbutaline, when administered intravenously or orally, did not potentiate the effect of inhaled terbutaline in asthmatics. The potentiation seen with intravenous and oral pretreatment was likely due to the different routes of administration, which may have improved the distribution of inhaled terbutaline.
Paper Details　
Original Abstract of the Article :
The influence of pretreatment with equipment bronchodilating doses of intravenous theophyllamine and inhaled terbutaline on the effect of five terbutaline inhalations was investigated in a cross-over study in six adult asthmatics with stable and reproducible bronchoconstriction. Theophylline in a do...See full text at original site
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引用元：
https://doi.org/10.1111/j.1398-9995.1982.tb01883.x

データ提供：米国国立医学図書館（NLM）

Theophylline and Inhaled Beta 2-Agonists: Exploring Interactions in Asthma Treatment

Asthma is a chronic respiratory condition that requires careful management. This research investigates the potential interactions between theophylline, a bronchodilator, and inhaled beta 2-agonists, another class of bronchodilators. The study aimed to determine whether pretreatment with theophylline would potentiate the effects of inhaled terbutaline, a commonly used beta 2-agonist. The authors found that while theophylline itself did not significantly potentiate the effects of inhaled terbutaline, the route of administration played a role in the observed effects.

Theophylline and Inhaled Beta 2-Agonists: A Complex Interaction

Think of the desert as a vast and intricate landscape, where each element plays a role in the overall environment. In the realm of asthma treatment, theophylline and inhaled beta 2-agonists are two key components, but their interactions can be complex and influenced by factors such as route of administration.

Navigating Asthma Management: A Multifaceted Approach

Managing asthma effectively requires a comprehensive understanding of the different medications used and their potential interactions. It's like a camel navigating a challenging desert, where each step must be taken with caution and precision. This research provides valuable insights into the complex interactions between theophylline and inhaled beta 2-agonists, reminding us of the importance of careful medication management in asthma care.

Dr.Camel's Conclusion

This study sheds light on the complex interactions between theophylline and inhaled beta 2-agonists, highlighting the importance of considering the route of administration when evaluating their effects in asthma treatment. It's like a camel carefully choosing its path through the desert, ensuring that each step leads towards a safer and more effective outcome.

Date :
  1. Date Completed 1982-12-16
  2. Date Revised 2019-08-21
Further Info :

Pubmed ID

6127963

DOI: Digital Object Identifier

10.1111/j.1398-9995.1982.tb01883.x

SNS
PICO Info
in preparation
Languages

English

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