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Effects of oral theophylline combined with oral and inhaled beta-2-adrenostimulants in asthmatics.

Author: SvedmyrK

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A combination of low-dose oral terbutaline and theophylline was more effective in treating asthma than a high dose of terbutaline alone, with significantly less tremor. The combination provided an additional bronchodilating effect when inhaled terbutaline was added.
Paper Details　
Original Abstract of the Article :
The acute ventilatory, cardiovascular and tremorogenic effect of a high oral dose of terbutaline (5 mg) was compared with that of half the dose (2.5 mg) combined with 280 mg anhydrous theophylline orally in the randomized, double-blind, cross-over study in eight asthmatics. After 120 min, when stead...See full text at original site
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引用元：
https://doi.org/10.1111/j.1398-9995.1982.tb01885.x

データ提供：米国国立医学図書館（NLM）

Combining Theophylline and Beta-2-Adrenostimulants for Asthma Treatment

This research focuses on optimizing asthma treatment by combining two different types of medications: theophylline and beta-2-adrenostimulants. It’s like a skilled desert traveler combining multiple resources to navigate a challenging terrain. The study investigates the combined effects of these medications on respiratory function and side effects in asthmatic patients. The results suggest that combining low doses of both medications can provide effective bronchodilation with fewer side effects compared to using high doses of either medication alone. This is a valuable finding that could improve the lives of many asthmatic individuals.

Optimizing Asthma Treatment

The study revealed that a combination of oral theophylline and inhaled beta-2-adrenostimulants, in sub-optimal doses, led to significant improvement in bronchodilation with minimal side effects. It’s like finding a hidden oasis in the desert, providing much-needed relief and refreshment. The researchers discovered that this combination approach could be especially beneficial for patients who do not respond well to high doses of a single medication.

Improving Asthma Management

The findings of this study have implications for the management of asthma. It’s like discovering a new route through the desert, providing a smoother and safer path for travelers. The study suggests that combining different types of medications in a controlled and tailored manner can be a more effective and safer approach to asthma treatment. This information could benefit asthmatic patients by improving their quality of life and reducing the burden of their condition.

Dr.Camel's Conclusion

This research offers a valuable perspective on asthma treatment strategies. It’s like navigating a desert with multiple routes, each with its own advantages and disadvantages. The study suggests that combining different medications in carefully adjusted doses can provide optimal results while minimizing side effects. This approach could lead to more effective and personalized treatment plans for asthmatic patients.

Date :
  1. Date Completed 1982-12-16
  2. Date Revised 2019-08-21
Further Info :

Pubmed ID

6127964

DOI: Digital Object Identifier

10.1111/j.1398-9995.1982.tb01885.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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