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Selective effects of buspirone and molindone on dopamine metabolism and function in the striatum and frontal cortex of the rat.

Author: McDonaldC C, McMillenB A

Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Dopamine autoreceptors were found to be absent in the frontal cortex, while present in the striatum. Buspirone, a non-benzodiazepine anti-anxiety drug, reversed catalepsy by enhancing dopamine release, suggesting potential for treating extrapyramidal motor disorders.
Paper Details　
Original Abstract of the Article :
The hypothesis that the nerve endings of the dopamine projection of the frontal cortex lack autoreceptors for regulation of tyrosine hydroxylase was tested by using the preferential inhibitors of dopamine autoreceptors, molindole and buspirone. In contrast to haloperidol, which elevates dopamine met...See full text at original site
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引用元：
https://doi.org/10.1016/0028-3908(83)90240-x

データ提供：米国国立医学図書館（NLM）

Buspirone and Molindone: Exploring Dopamine Modulation

Dopamine, a neurotransmitter, plays a crucial role in various brain functions, including movement, mood, and reward. This research investigates the effects of buspirone and molindone, two medications with distinct pharmacological profiles, on dopamine metabolism and function in specific brain regions.

Buspirone and Molindone: Distinct Effects on Dopamine Pathways

The study’s findings reveal that buspirone and molindone exert selective effects on dopamine pathways in the brain. Buspirone, a non-benzodiazepine anti-anxiety drug, shows potential for treating extrapyramidal motor disorders, highlighting its unique mechanism of action.

Dopamine: A Vital Neurotransmitter

Understanding the intricacies of dopamine pathways is essential for developing effective treatments for a wide range of neurological and psychiatric disorders. This research provides valuable insights into the complex interplay of medications and dopamine neurotransmission, paving the way for future advancements in therapeutic strategies.

Dr.Camel's Conclusion

Exploring the intricate network of dopamine pathways is like traversing a vast desert, uncovering hidden secrets that hold the key to understanding brain function. This study illuminates the distinct effects of buspirone and molindone on dopamine pathways, offering valuable insights for developing novel therapies.

Date :
  1. Date Completed 1983-06-10
  2. Date Revised 2019-07-26
Further Info :

Pubmed ID

6133232

DOI: Digital Object Identifier

10.1016/0028-3908(83)90240-x

Related Literature

Article Analysis
・Effects of molindone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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