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Reinforcing properties of oral delta 9-tetrahydrocannabinol, smoked marijuana, and nabilone: influence of previous marijuana use.

Author: MelloN K, MendelsonJ H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

The study showed that smoked marijuana was significantly more reinforcing than other cannabis compounds, regardless of marijuana use history. Regular users experienced increased elation, while intermittent and occasional users showed increased pulse rate.
Paper Details　
Original Abstract of the Article :
The reinforcing properties of delta 9THC (17.5 mg), a 1 g marijuana cigarette containing 1.83% delta 9-THC, a synthetic cannabis compound (Nabilone 2 mg orally), and their respective placebos were assessed with self-report and operant work-contingent choice procedures. Three groups of eight subjects...See full text at original site
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引用元：
https://doi.org/10.1007/BF00428544

データ提供：米国国立医学図書館（NLM）

Reinforcing Properties of Cannabis Compounds: The Influence of Past Use

This research delves into the fascinating world of cannabis and its reinforcing properties. The researchers investigated the effects of different cannabis compounds, including delta 9-tetrahydrocannabinol (delta 9-THC), smoked marijuana, and nabilone, on subjects with varying histories of marijuana use. They used self-report and operant work-contingent choice procedures to assess the reinforcing properties of these compounds. Their primary objective was to determine how past marijuana use influenced the reinforcing properties of cannabis compounds and their behavioral and physiological effects.

The study found that past marijuana use had a significant impact on the reinforcing properties of cannabis compounds. Regular marijuana users reported increased elation following marijuana smoking, while intermittent and occasional users experienced significant increases in pulse rate. Nabilone and delta 9-THC produced significant increases in pulse rate for all subject groups, but no significant increase in elation. Furthermore, in an operant work choice paradigm, subjects consistently worked to obtain a marijuana cigarette, indicating its strong reinforcing properties.

The Reinforcing Power of Cannabis: A Desert Oasis of Pleasure

This research, like a camel traversing the vast desert of cannabis research, reveals the complex interplay between past marijuana use and the reinforcing properties of cannabis compounds. The study's findings highlight the importance of considering individual histories of drug use when evaluating the effects of cannabis.

The Allure of Cannabis: A Desert Mirage of Pleasure

This research, like a desert mirage shimmering in the heat, explores the allure of cannabis and its reinforcing properties. The study's findings underscore the strong reinforcing effects of marijuana, particularly for individuals with a history of regular use. This research provides valuable insights into the complex relationship between cannabis and human behavior.

Dr.Camel's Conclusion

This research, like a camel navigating the shifting sands of cannabis research, reveals the fascinating interplay between past marijuana use and the reinforcing properties of cannabis compounds. The study's findings highlight the importance of understanding the complex relationship between cannabis and human behavior.

Date :
  1. Date Completed 1984-12-12
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

6149589

DOI: Digital Object Identifier

10.1007/BF00428544

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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