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Hepatitis B vaccine in health care personnel: safety, immunogenicity, and indicators of efficacy.

Author: CravenD E, CrumpackerC S, DienstagJ L, GradyG F, Ouellet-HellstromR, PlattR, PolkB F, SnydmanD R, WernerB G

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Hepatitis B vaccine (20 micrograms) was highly immunogenic and safe in healthcare workers. 58% of recipients responded within 1 month and 97% within 9 months. The vaccine group experienced a 67% reduction in the need for hepatitis B immune globulin after accidental inoculation.
Paper Details　
Original Abstract of the Article :
In a double-blind trial, we randomly assigned 1330 high-risk health care personnel to receive three 20-micrograms doses of hepatitis B vaccine or placebo. Among vaccine recipients 58% responded within 1 month and 97% within 9 months; there was no difference in immune response to the vaccine between ...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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引用元：
https://doi.org/10.7326/0003-4819-101-1-34

データ提供：米国国立医学図書館（NLM）

Hepatitis B Vaccine: Protecting Against a Silent Threat

Hepatitis B, a potentially serious viral infection, can silently spread through the desert of our communities. This study investigates the safety and efficacy of a hepatitis B vaccine in healthcare workers, a group at high risk of exposure. The research found that the vaccine is highly immunogenic, effectively protecting against the virus, and safe, with minimal side effects. This study offers valuable insights into the importance of vaccination programs in preventing the spread of infectious diseases.

Vaccination: A Shield Against Disease

The study demonstrates the vital role of vaccination in safeguarding public health. It's like building a protective wall against the harsh desert winds, protecting us from the dangers that lurk beyond.

Building Immunity: Our Collective Oasis

This research reminds us that vaccination is not only a personal choice but also a social responsibility. It's like building a shared oasis in the vast desert of our collective well-being, ensuring that everyone has access to safe and effective protection against infectious diseases.

Dr. Camel's Conclusion

This study underscores the crucial role of vaccination in safeguarding our health and building a stronger community. It's like establishing a network of oases in the desert, offering a safe haven from the threats that surround us.
Date :
  1. Date Completed 1984-07-17
  2. Date Revised 2019-06-19
Further Info :

Pubmed ID

6233921

DOI: Digital Object Identifier

10.7326/0003-4819-101-1-34

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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