Haemodynamic dose-response effects of i.v. penbutolol in angina pectoris.

Author: HussainM, NelsonG I, OkoliR C, SilkeB, TaylorS H, VermaS P

Paper Details 
Original Abstract of the Article :
The haemodynamic dose-response effects of intravenous penbutolol, a newer beta-adrenoceptor antagonist with intrinsic sympathomimetic activity but without cardioselectivity, were evaluated in 10 patients with angiographically documented coronary artery disease. Following four logarithmetically cumul...See full text at original site
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引用元:
https://doi.org/10.1111/j.1365-2125.1983.tb02211.x

データ提供:米国国立医学図書館(NLM)

The Haemodynamic Dose-Response Effects of Penbutolol in Angina Pectoris

In the realm of [cardiology], the quest for safe and effective treatments for [angina pectoris] is an ongoing journey. This study investigates the [haemodynamic effects] of [penbutolol], a [beta-adrenoceptor antagonist], in patients with [coronary artery disease]. Imagine a camel traversing a desert landscape, its heart beating rapidly in response to the intense heat and exertion. This study delves into the delicate balance of blood flow and heart function, examining the impact of a specific drug on these vital aspects of cardiovascular health.

Exploring the Impact of Penbutolol on Heart Function

This study provides valuable insights into the [dose-response effects] of penbutolol, revealing its potential benefits and limitations in treating [angina pectoris]. The researchers found that penbutolol effectively reduced heart rate and attenuated exercise-induced [angina] while maintaining a relatively modest depression of cardiac performance. These findings highlight the potential of penbutolol as a promising treatment option for managing [angina], balancing the need for symptom relief with the preservation of overall heart function.

Navigating the Complexities of Cardiovascular Medications

This study underscores the importance of understanding the specific effects of cardiovascular medications on individual patients. It emphasizes the need for careful dose adjustments and monitoring to ensure optimal therapeutic outcomes while minimizing potential adverse effects. This research is a reminder that the desert of cardiology is a complex and intricate landscape, requiring a nuanced understanding of individual patient needs and a personalized approach to treatment.

Dr. Camel's Conclusion

This study is a reminder that navigating the desert of cardiology requires a delicate balance between managing symptoms and preserving overall heart health. Penbutolol, like a well-trained camel traversing a challenging terrain, demonstrates the potential for effective treatment of [angina] while minimizing the impact on overall cardiac performance. It underscores the importance of careful dose adjustment and personalized care in managing cardiovascular conditions.

Date :
  1. Date Completed 1984-01-07
  2. Date Revised 2019-05-11
Further Info :

Pubmed ID

6315039

DOI: Digital Object Identifier

10.1111/j.1365-2125.1983.tb02211.x

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Languages

English

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