The effects of antacid and propantheline on the absorption of oral ranitidine.

Author: DonnK H, EshelmanF N, FabreL, PlachetkaJ R, PowellJ R

Paper Details 
Original Abstract of the Article :
The effects of propantheline bromide and an aluminum hydroxide/magnesium hydroxide suspension on absorption of ranitidine were evaluated in 12 healthy volunteers according to a Latin square design. Ranitidine 150 mg was administered alone, with 30 ml antacid or preceded by 15 mg propantheline. Ten s...See full text at original site
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引用元:
https://doi.org/10.1002/j.1875-9114.1984.tb03326.x

データ提供:米国国立医学図書館(NLM)

The Impact of Antacids and Propantheline on Ranitidine Absorption

This research delves into the fascinating world of drug interactions. It specifically investigates how common medications like antacids and propantheline affect the absorption of ranitidine, a widely used drug for treating ulcers. The study employed a Latin square design, a clever strategy that helps researchers control for potential biases. They discovered that antacids had no significant impact on ranitidine absorption, but propantheline increased its bioavailability by 22%. While propantheline also tended to increase the maximum ranitidine concentration in the blood and delay its peak, these observations didn't reach statistical significance. This study provides valuable insights into how these medications might interact with each other, which is crucial information for doctors and patients alike.

Propantheline: A Game Changer for Ranitidine?

This research sheds light on the interesting interaction between ranitidine and propantheline. Propantheline actually boosted the amount of ranitidine absorbed by the body. This finding could potentially lead to new strategies for optimizing ranitidine treatment, ensuring maximum effectiveness. It's like adding a little extra fuel to the fire, helping ranitidine work its magic even better!

Ranitidine: Safe for Most, but Watch Out for Propantheline

This research suggests that ranitidine can be safely taken along with antacids. However, it's important to be cautious when combining it with propantheline. Since propantheline can affect ranitidine's absorption, careful monitoring might be necessary. Think of it like mixing different flavors in a delicious dessert - some combinations work beautifully, while others might need a little adjustment. Always consult your doctor for personalized guidance.

Dr.Camel's Conclusion

This study emphasizes the importance of understanding drug interactions. Just like a camel navigating a vast desert, our bodies are complex ecosystems, and medications can have intricate effects on each other. It's essential to consult healthcare professionals to ensure optimal medication choices and prevent any unexpected side effects.

Date :
  1. Date Completed 1984-06-21
  2. Date Revised 2019-09-13
Further Info :

Pubmed ID

6326064

DOI: Digital Object Identifier

10.1002/j.1875-9114.1984.tb03326.x

Related Literature

SNS
PICO Info
in preparation
Languages

English

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