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Toxicity and side-effects of antimalarials in Africa: a critical review.

Author: SalakoL A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Chloroquine is widely used for malaria prophylaxis in Africa, despite the emergence of resistance in some areas. Pruritus is a common side effect, and prolonged use raises concerns about ocular toxicity. Pyrimethamine-sulfadoxine is another antimalarial used in Africa, and prolonged use might lead to side effects associated with sulfonamides. Genetic factors might contribute to the severity of adverse reactions to some antimalarials, such as primaquine and quinine.
Paper Details　
Original Abstract of the Article :
Notwithstanding the presence of resistance to chloroquine in some parts of Africa, this drug is still the most widely used antimalarial in the continent. One adverse reaction of chloroquine that has an important bearing on its use is pruritus. The risk of increasing the incidence of ocular toxicity ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2536191/

データ提供：米国国立医学図書館（NLM）

Antimalarials in Africa: A Balancing Act of Benefits and Risks

Malaria, a mosquito-borne disease, remains a major health concern in Africa. This study examines the toxicity and side effects of antimalarial drugs, particularly chloroquine and pyrimethamine-sulfadoxine, which are widely used in the region.

The study explores the potential risks associated with these drugs, analyzing their adverse effects and considering factors like genetic predisposition. It's like navigating a desert filled with hidden dangers, carefully assessing each step to avoid potential hazards.

Navigating the Risks of Antimalarial Drugs

The study highlights the need for careful monitoring and management of antimalarial drug use, recognizing the potential for adverse effects, especially with prolonged use. It's like navigating a desert landscape, being aware of the potential hazards and taking precautions to minimize the risks.

Balancing Benefits and Risks

This study underscores the importance of balancing the benefits of antimalarial drugs with the potential for adverse effects. It's like finding a safe passage through a desert, carefully weighing the risks and rewards of each path.

Dr.Camel's Conclusion

This review sheds light on the complexities of antimalarial drug use in Africa, highlighting the need for careful monitoring and management to ensure both efficacy and safety. It's like navigating a desert landscape, where understanding the terrain and preparing for potential hazards is crucial for a successful and healthy journey.

Date :
  1. Date Completed 1985-05-13
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

6335683

DOI: Digital Object Identifier

PMC2536191

Related Literature

Article Analysis
・Side Effects of primaquine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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