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Combination of salbutamol inhalational powder and tablets in asthma.

Author: DawsonK P, FergussonD M, GrimwoodK

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

In a study of asthmatic children, salbutamol delivered via a combination of dry powder inhalation and tablets showed rapid onset and sustained action. Tablet-only treatment had a slower but sustained effect, while powder inhalation had a rapid but shorter effect. Combined treatment was found to be an additive combination of both components.
Paper Details　
Original Abstract of the Article :
A double-blind cross-over trial was conducted to assess the effects of salbutamol administered by inhalation of dry powder, by tablet, and combined tablet and inhalational powder in a sample of 18 severely asthmatic children. The combined treatment had a rapid onset of effect and sustained action. T...See full text at original site
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引用元：
https://doi.org/10.1136/adc.58.4.283

データ提供：米国国立医学図書館（NLM）

Theophylline: A Multifaceted Approach to Asthma

Asthma, a common respiratory condition, requires a multifaceted approach to manage its symptoms effectively. This study examines the efficacy and safety of different theophylline formulations in children with severe asthma. The researchers conducted a double-blind cross-over trial, comparing the effects of inhaled dry powder, oral tablets, and a combination of both.

Tailoring Theophylline Treatment for Optimal Outcomes

The study demonstrated that the combination of inhaled dry powder and oral tablets provided the most rapid onset of action and sustained effect. The researchers found that the combination treatment was an additive function of its individual components, offering a tailored approach to asthma management. While both the combined treatment and oral tablets showed a slight increase in heart rate, other side effects were minimal.

Navigating Asthma Management

Asthma management is a complex journey, requiring personalized approaches to control symptoms and maintain quality of life. This study provides valuable insights into the efficacy and safety of different theophylline formulations, offering clinicians a wider range of options to tailor treatment to individual patient needs. It's a reminder that the desert of asthma research is continually evolving, revealing new pathways for effective management and improved outcomes.

Dr. Camel's Conclusion

This study emphasizes the importance of finding the right combination of medications to manage asthma effectively. The researchers' findings provide a roadmap for tailoring theophylline treatment to individual patient needs, offering a more personalized and effective approach to asthma management. It's a reminder that the quest for better asthma treatments continues, and the desert of medical knowledge offers endless possibilities for innovation and progress.
Date :
  1. Date Completed 1983-06-23
  2. Date Revised 2019-05-01
Further Info :

Pubmed ID

6342544

DOI: Digital Object Identifier

10.1136/adc.58.4.283

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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