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Efficacy of a heat inactivated hepatitis B vaccine in male homosexuals: outcome of a placebo controlled double blind trial.

Author: Albrecht-Van LentP, CoutinhoR A, DeesP, HuismanJ, LelieN, NivardJ, Reerink-BrongersE E, ReesinkH W, StoutjesdijkL

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A hepatitis B vaccine containing 3 micrograms HBsAg reduced the incidence of hepatitis B infections in 800 homosexual men by 80% compared to placebo. The vaccine was well tolerated and showed no serious side effects.
Paper Details　
Original Abstract of the Article :
The efficacy of a heat inactivated hepatitis B virus vaccine, containing 3 micrograms hepatitis B surface antigen (HBsAg), was studied in a high risk group of 800 susceptible homosexual men by a randomised placebo controlled double blind trial. At the trial end point (21.5 months), 17 hepatitis B vi...See full text at original site
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引用元：
https://doi.org/10.1136/bmj.286.6374.1305

データ提供：米国国立医学図書館（NLM）

The Efficacy of a Heat Inactivated Hepatitis B Vaccine in Male Homosexuals

This research delves into the realm of immunology and public health, exploring the effectiveness of a heat-inactivated hepatitis B vaccine in a high-risk group of homosexual men. The study employed a randomized, placebo-controlled, double-blind trial, a rigorous methodology akin to navigating a desert with a compass and map. The researchers sought to unravel the intricate pathways of vaccine efficacy and its impact on disease prevention. Their findings revealed a significant reduction in hepatitis B virus infections among vaccinated individuals, a beacon of hope in the arid landscape of infectious diseases. This discovery is a testament to the power of scientific inquiry in combating health threats.

A Significant Reduction in Hepatitis B Infections

The study reported a remarkable 4.8% attack rate in the vaccinated group compared to a 23.8% attack rate in the placebo group. This translates to a statistically significant difference (p < 0.0001), a finding as clear as the starry night sky in a desert oasis. This difference underscores the effectiveness of the vaccine in mitigating the risk of hepatitis B infection.

Preventing Hepatitis B: A Public Health Triumph

The results of this study serve as a reminder of the critical role vaccination plays in safeguarding public health. Like a well-maintained irrigation system, vaccines deliver a vital protective shield against infectious diseases. This research highlights the importance of targeted vaccination programs, especially in high-risk populations, to prevent the spread of diseases and improve overall health outcomes.

Dr. Camel's Conclusion

This research serves as a powerful reminder of the immense benefits of vaccination. It's like a camel caravan traversing a harsh desert, armed with a life-giving oasis of protection against disease. This study underscores the crucial role vaccination plays in safeguarding public health, especially for vulnerable populations.

Date :
  1. Date Completed 1983-06-10
  2. Date Revised 2019-05-01
Further Info :

Pubmed ID

6404440

DOI: Digital Object Identifier

10.1136/bmj.286.6374.1305

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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