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Dose-response analysis of the behavioral effects of diazepam: II. Psychomotor performance, cognition and mood.

Author: GhoneimM M, HinrichsJ V, MewaldtS P

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Diazepam impaired psychomotor and cognitive function in a dose-dependent manner. The drug affected speed of performance rather than accuracy. No tranquilizing effects were reported, suggesting that the anxiolytic effects of diazepam cannot be studied in healthy volunteers.
Paper Details　
Original Abstract of the Article :
The psychomotor, cognitive, and mood effects of orally administered diazepam and placebo were measured over approximately equal to 3.5 h. A total of 120 volunteers were assigned to 12 groups of 10 each, representing the combination of four treatments (placebo, 0.1, 0.2, and 0.3 mg/kg diazepam) and t...See full text at original site
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引用元：
https://doi.org/10.1007/BF00427673

データ提供：米国国立医学図書館（NLM）

The Effects of Diazepam: A Detailed Look at Psychomotor Performance, Cognition, and Mood

This study investigates the effects of diazepam, a commonly used anxiolytic drug, on various aspects of human performance, including psychomotor skills, cognitive abilities, and mood. Imagine diazepam as a calming oasis in the midst of a chaotic desert, soothing the mind and altering its functions. This study aims to provide a comprehensive understanding of the drug's impact, exploring its dose-response effects and potential for impairment.

Diazepam: A Dose-Dependent Impact on Performance

The authors conducted a [research methodology] to assess the effects of diazepam on psychomotor performance, cognition, and mood. Their findings reveal a consistent dose-response relationship, with higher doses leading to greater impairments in psychomotor and cognitive functions.

Understanding the Impact of Diazepam: Implications for Use

This study highlights the importance of considering the potential side effects of diazepam, especially its impact on psychomotor skills and cognitive abilities. The authors recommend careful dosage adjustments and monitoring, particularly in situations where these functions are critical.

Dr. Camel's Conclusion

This study serves as a reminder that even seemingly benign medications can have significant impacts on human performance. It emphasizes the need for a balanced approach to diazepam use, carefully weighing its potential benefits against its potential drawbacks.
Date :
  1. Date Completed 1984-07-09
  2. Date Revised 2019-07-26
Further Info :

Pubmed ID

6427817

DOI: Digital Object Identifier

10.1007/BF00427673

Related Literature

Article Analysis
・Effects of diazepam
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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