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Effects of cephalexin, erythromycin and clindamycin on the aerobic Gram-negative faecal flora in man.
Author: ClementsH M, HartleyC L, LintonK B
Original Abstract of the Article :
The effects of 5-day courses of orally administered cephalexin, clindamycin and erythromycin on the Gram-negative, aerobic faecal flora of healthy adults were examined. The concentration of cephalexin reached in the intestine was high enough to cause the emergence of resistant Gram-negative bacteria...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1099/00222615-11-2-125
データ提供:米国国立医学図書館(NLM)
The Impact of Antibiotics on the Gut Microbiome: A Desert Ecosystem in Flux
Antibiotics are powerful tools for fighting infections, but they can also have unintended consequences. This research explores the effects of three different antibiotics—cephalexin, erythromycin, and clindamycin—on the aerobic Gram-negative faecal flora in humans. Think of this as a group of scientists studying the delicate balance of a desert ecosystem, investigating how different interventions might disrupt or alter this complex web of life.
Antibiotics: Disrupting the Desert Ecosystem
The study found that each antibiotic had a distinct impact on the faecal flora, with some causing a significant increase in resistant bacteria while others led to a reduction in specific bacterial groups. These findings highlight the potential for antibiotics to disrupt the delicate balance of the gut microbiome. This is similar to introducing a new species or disrupting the natural flow of water in a desert ecosystem, which can lead to unforeseen consequences.
Health Implications and Everyday Applications
This research underscores the importance of using antibiotics judiciously and being mindful of their potential impact on the gut microbiome. Just as a camel caravan needs to carefully manage its water resources to survive in the desert, we need to use antibiotics responsibly to minimize their potential for disrupting the balance of our own internal ecosystems.
Dr. Camel's Conclusion
This research provides a glimpse into the complex interplay between antibiotics and the gut microbiome. Just as a desert ecosystem is constantly in flux, our internal environment is highly dynamic and sensitive to external influences. We need to be aware of the potential consequences of antibiotic use and strive to use these powerful medications responsibly.
Date :
- Date Completed 1978-08-14
- Date Revised 2013-11-21
Further Info :
Related Literature
English
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