[Saluretic and diuretic effects of xipamide-triamterene combinations in varying dose ratios in rats].

Author: ArmahB, DiesR, HeinzN

Paper Details 
Original Abstract of the Article :
The saluretic and diuretic properties of 4-chloro-5-sulfamoyl-2',6'-salicyloxylidide (xipamide) and 2,4,7-triamino-6-phenyl-pteridine (triamterene) were determined in rats following sole and combined application in various dosages and dose ratios. Xipamide dosages ranged from 0.01-30 mg/kg body weig...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/6681965

データ提供:米国国立医学図書館(NLM)

Xipamide-Triamterene Combinations: Exploring Saluretic and Diuretic Effects

The desert of diuretic research is a vast and complex landscape, with many different pathways and solutions to explore. This study examines the saluretic and diuretic effects of xipamide-triamterene combinations in rats, testing various dose ratios to find the most effective approach. This research is like a group of scientists experimenting with different irrigation techniques in a desert environment, seeking to find the best way to optimize water flow and utilization.

Exploring the Interactions of Xipamide and Triamterene

The researchers found that combining xipamide and triamterene resulted in an enhanced sodium excretion, suggesting a synergistic effect between these two diuretics. This is like discovering that two different types of irrigation systems, when combined, can create a more efficient and effective flow of water throughout the desert. This study highlights the potential benefits of combining these diuretics for managing fluid imbalances.

Navigating the Desert of Diuretic Therapy

The study also found that the combination of xipamide and triamterene can affect potassium levels, highlighting the importance of monitoring potassium levels carefully. This is like being aware of the potential for salinization in a desert environment, where excessive irrigation can lead to a buildup of salts. This study emphasizes the need for careful monitoring and adjustments in diuretic therapy to ensure optimal patient outcomes.

Dr. Camel's Conclusion

This study delves into the complexities of diuretic therapy, exploring the interactions and potential benefits of different combinations. It's like uncovering a new and more efficient irrigation system in the desert, offering a more effective way to manage fluid balance. However, it's crucial to approach diuretic therapy with caution, carefully monitoring potassium levels and adjusting treatment plans as needed to ensure optimal patient outcomes. Remember, just as a desert environment requires careful management of water resources, diuretic therapy requires a thoughtful and personalized approach.

Date :
  1. Date Completed 1983-04-21
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

6681965

DOI: Digital Object Identifier

6681965

Related Literature

SNS
PICO Info
in preparation
Languages

German

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