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Comparison of effects of nifedipine, propantheline bromide, and the combination on esophageal motor function in normal volunteers.

Author: HongoM, McCallumR W, TraubeM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Nifedipine had a greater effect on lower esophageal sphincter pressure than propantheline bromide, while propantheline bromide had a greater effect on esophageal contraction amplitude. The combination of the two drugs had an enhanced effect on both parameters.
Paper Details　
Original Abstract of the Article :
Both intracellular calcium ions and neural input are important in esophageal smooth muscle contraction. The aim of this study was to compare the effects of well-tolerated doses of the calcium-channel blocker, nifedipine (20 mg sublingually/buccally) with the anticholinergic, propantheline bromide (1...See full text at original site
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引用元：
https://doi.org/10.1007/BF01318513

データ提供：米国国立医学図書館（NLM）

Comparing the Effects of Medications on Esophageal Motor Function: A Deep Dive

This study takes us on a journey into the complex world of esophageal motor function, a vital process that allows us to swallow food and beverages. The researchers are exploring the effects of different medications on esophageal muscle contraction, which is like studying the intricate dance of the desert wind that shapes the dunes.

Understanding the Mechanism of Action

The study compared the effects of nifedipine, a calcium-channel blocker, propantheline bromide, an anticholinergic, and a combination of the two on esophageal motor function. This research is like analyzing different types of desert plants to understand their unique adaptations to their environment. The study found that nifedipine had a greater effect on the lower esophageal sphincter, while propantheline bromide had a greater effect on esophageal contraction amplitude.

Optimizing Treatment Strategies for Esophageal Disorders

This study provides valuable insights into the mechanisms of action of different medications on esophageal motor function. This knowledge is crucial for developing optimal treatment strategies for patients with esophageal disorders. It's like understanding the interplay between the desert wind and the shifting dunes, allowing us to better predict and navigate potential changes in the landscape.

Dr.Camel's Conclusion

This research provides a comprehensive analysis of the effects of different medications on esophageal motor function, offering valuable insights for optimizing treatment strategies for patients with esophageal disorders. It's like finding a reliable map for navigating the complex desert landscape of esophageal function, helping us understand and manage the intricacies of this vital process.
Date :
  1. Date Completed 1984-05-11
  2. Date Revised 2019-07-21
Further Info :

Pubmed ID

6705640

DOI: Digital Object Identifier

10.1007/BF01318513

Related Literature

Article Analysis
・Effects of propantheline
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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