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The clinical efficacy and side-effects of mianserin and nortriptyline in depressed out-patients: a double-blind randomized trial.

Author: HocJ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Mianserin and nortriptyline were both effective antidepressants. However, mianserin was much better tolerated, with significantly fewer side effects such as tachycardia, dry mouth, constipation, sweating, insomnia, agitation, and edema.
Paper Details　
Original Abstract of the Article :
A double-blind randomized study was performed in 86 depressed out-patients, in order to compare the efficacy and tolerance of mianserin (30 to 60 mg daily) with that of nortriptyline (75 to 150 mg daily). Both drugs were administered for 6 weeks after a wash-out period of 1 week. The Hamilton Rating...See full text at original site
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引用元：
https://doi.org/10.1185/03007998209109779

データ提供：米国国立医学図書館（NLM）

Mianserin vs. Nortriptyline: A Desert Race for Depression Relief

The desert of depression can be a lonely and isolating place, leaving many seeking relief. This double-blind randomized trial, like a desert race, pits two medications, [mianserin and nortriptyline], against each other to see which one can offer the most effective path to recovery. The researchers found that [both medications were effective in treating depressed out-patients], offering a valuable oasis of relief in this challenging landscape.

A Neck-and-Neck Race

The study found that [both mianserin and nortriptyline had similar efficacy in reducing depressive symptoms], with [mianserin demonstrating better tolerability]. This is like a camel race where both competitors reach the finish line, but one camel is less likely to suffer from side effects. This suggests that [mianserin may offer a more comfortable and better-tolerated treatment option for depression], offering a smoother and more enjoyable journey through the desert of mental health.

Navigating the Desert of Depression

This research emphasizes the importance of [individualized treatment approaches] for depression, recognizing that each patient's journey through the desert of mental health is unique. It's like recognizing that each traveler in the desert needs a different approach, taking into account their specific needs and preferences. By working with a healthcare professional, patients can find the best oasis of treatment options to alleviate their symptoms and improve their quality of life.

Dr. Camel's Conclusion

This study is a valuable guide for navigating the desert of depression. It reminds us that we have valuable tools at our disposal, like mianserin and nortriptyline, that can help us find relief from this challenging condition. By approaching depression with early intervention and appropriate treatment, we can potentially reduce the suffering and ensure a smoother and more comfortable journey for our patients.

Date :
  1. Date Completed 1983-03-24
  2. Date Revised 2019-09-08
Further Info :

Pubmed ID

6759061

DOI: Digital Object Identifier

10.1185/03007998209109779

Related Literature

Article Analysis
・Side Effects of nortriptyline
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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