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Hormonal effects of different doses of estramustine phosphate (Estracyt) in patients with prostatic carcinoma.

Author: CekanS Z, DiczfalusyE, FritjofssonA, HögbergB, NorlénB J, RajalakshmiM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the hormonal effects of estramustine phosphate (Estracyt) in 10 patients with previously untreated prostatic carcinoma. Estracyt reduced testosterone levels significantly, with a maximal effect achieved at a dose of 70 mg/day. The most common side effects were edema and refractoriness to therapy.
Paper Details　
Original Abstract of the Article :
Ten patients with previously untreated prostatic carcinoma were studied to evaluate the hormonal effects of different doses of estramustine phosphate (Estracyt). The drug was given by mouth in increasing doses; during the first month 70 mg daily, during the second 140 mg, during the third 280 mg and...See full text at original site
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引用元：
https://doi.org/10.3109/00365598109181211

データ提供：米国国立医学図書館（NLM）

Hormonal Effects of Estramustine Phosphate in Prostatic Carcinoma

Estramustine phosphate (Estracyt), a hormonal therapy for prostatic carcinoma, has been shown to have a potent anti-tumor effect. This research investigates the hormonal effects of different doses of Estracyt in patients with previously untreated prostatic carcinoma. The study involved 10 patients who received increasing doses of Estracyt over a four-month period.

Hormonal Effects of Estramustine Phosphate

The results demonstrate that even the lowest dose of Estracyt significantly reduced testosterone levels and other hormone levels, indicating a potent hormonal effect. The study found that the maximum hormonal effect was achieved at the lowest dose, with no further reduction observed with higher doses. The clinical effect of the treatment was initially excellent, but complications and refractoriness led to discontinuation in some patients.

Understanding Estramustine Phosphate's Mechanism

This research provides valuable insights into the hormonal effects of Estracyt, highlighting its potent hormonal activity and potential benefits for managing prostatic carcinoma. It's like finding a hidden spring in the desert of prostate cancer research, revealing a promising avenue for developing more targeted and effective therapies.

Dr.Camel's Conclusion

This research sheds light on the hormonal effects of Estracyt, a valuable tool in the fight against prostate cancer. Understanding the mechanism of action of this drug is crucial for developing more effective and personalized therapies. It's like finding a hidden oasis in the desert, offering a potential solution to a challenging condition.

Date :
  1. Date Completed 1981-08-10
  2. Date Revised 2019-09-04
Further Info :

Pubmed ID

6787701

DOI: Digital Object Identifier

10.3109/00365598109181211

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Languages

English

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