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Overeating after midbrain 6-hydroxydopamine: prevention by central injection of selective catecholamine reuptake blockers.

Author: HernandezL, HoebelB G

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study investigated the role of norepinephrine depletion in hyperphagia and obesity induced by 6-hydroxydopamine (6-OHDA) in rats. Local injection of amphetamine or desmethylimipramine before 6-OHDA prevented hyperphagia and obesity by partially preventing catecholamine depletion in the forebrain.
Paper Details　
Original Abstract of the Article :
Earlier research from this laboratory showed that 6-hydroxydopamine (6-OHDA) injected into the ventral midbrain of rats causes overeating and the gradual development of obesity in association with extensive depletion of forebrain norepinephrine. It was proposed that depletion of norepinephrine or ep...See full text at original site
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引用元：
https://doi.org/10.1016/0006-8993(82)90816-2

データ提供：米国国立医学図書館（NLM）

Understanding the Role of Norepinephrine in Overeating

This research explores the complex interplay between neurotransmitters and feeding behavior, specifically focusing on the role of norepinephrine in regulating food intake. The study investigates the effects of 6-hydroxydopamine (6-OHDA), a neurotoxin that selectively destroys catecholamine neurons, on food intake and body weight in rats. The research aims to identify the specific brain regions and neurotransmitters involved in controlling overeating and to understand the mechanisms underlying this behavioral phenomenon.

Norepinephrine's Role in Regulating Food Intake

The study found that injecting 6-OHDA into the ventral midbrain of rats led to overeating and subsequent obesity, which was strongly correlated with the depletion of norepinephrine in the forebrain. Furthermore, the researchers observed that pretreating rats with selective catecholamine reuptake blockers, such as desmethylimipramine (DMI) and amphetamine, prevented the 6-OHDA-induced overeating. These findings suggest that norepinephrine plays a crucial role in inhibiting food intake, and its depletion can lead to overeating.

Managing Overeating and Obesity

This research highlights the complex interplay between neurotransmitters and feeding behavior. It underscores the importance of understanding the role of norepinephrine in regulating food intake and its potential contribution to overeating and obesity. Further research is needed to explore the therapeutic potential of targeting norepinephrine pathways to address these challenges. It's important to consult with healthcare providers for personalized guidance on managing weight and addressing potential underlying conditions that may contribute to overeating.

Dr.Camel's Conclusion

This research takes us on a fascinating journey through the desert of the brain, revealing the intricate connections between neurotransmitters and behavior. Understanding these connections can lead to new insights and potential therapeutic strategies for managing conditions such as overeating and obesity.

Date :
  1. Date Completed 1982-12-21
  2. Date Revised 2019-06-14
Further Info :

Pubmed ID

6812851

DOI: Digital Object Identifier

10.1016/0006-8993(82)90816-2

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English

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