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Protriptyline in the treatment of sleep apnoea.

Author: ConwayW A, PiccioneP, RothT, ZorickF

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Protriptyline, an antidepressant, was found to be effective in treating 4 patients with obstructive sleep apnoea. The drug significantly improved symptoms and sleep quality in these patients. However, 3 patients developed intolerable side effects, and the drug was not effective in 2 patients.
Paper Details　
Original Abstract of the Article :
Nine patients with obstructive sleep apnoea were treated with 5 to 20 mg of protriptyline each night for two to 18 months. In four patients, there was dramatic, sustained improvement in symptoms and measured sleep quality and apnoea frequency and duration. There was no improvement in two patients an...See full text at original site
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引用元：
https://doi.org/10.1136/thx.37.1.49

データ提供：米国国立医学図書館（NLM）

Protriptyline: A Potential Solution for Sleep Apnea

Sleep apnea, a condition characterized by pauses in breathing during sleep, can significantly disrupt the quality of life. This study explores the potential of protriptyline, a tricyclic antidepressant, in treating this common sleep disorder. Researchers investigated its effectiveness in a group of patients with obstructive sleep apnea, hoping to find a new avenue for treatment.

A Promising but Cautious Approach

The results of this study demonstrate that protriptyline can be beneficial for some patients with mild to moderate obstructive sleep apnea, leading to dramatic improvement in symptoms and measured sleep quality. However, the researchers also emphasize the need for careful monitoring and selection of patients, as some individuals may experience intolerable side effects or may not respond to treatment. This underscores the importance of personalized medicine and the need for a tailored approach.

Navigating the Sleep Apnea Landscape

The findings of this study highlight the potential of protriptyline as a treatment option for selected patients with sleep apnea. While further research is needed to fully understand its long-term effects and to identify optimal patient selection criteria, this study provides a promising avenue for exploring alternative therapies for this common and often debilitating sleep disorder.

Dr.Camel's Conclusion

Just as a camel can withstand the harsh conditions of the desert, protriptyline shows promise in alleviating the challenges of sleep apnea. This study reveals a potential path for treating this common disorder, but it emphasizes the importance of careful consideration and personalized approaches for optimal outcomes.

Date :
  1. Date Completed 1982-06-14
  2. Date Revised 2019-05-03
Further Info :

Pubmed ID

7071794

DOI: Digital Object Identifier

10.1136/thx.37.1.49

Related Literature

Article Analysis
・Side Effects of protriptyline
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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