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Effects of estramustine and megestrol on ultrastructure of rat ventral prostate.

Author: ChaiL S, DinchukJ E, KarrJ P, MurphyG P, SandbergA A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Estramustine phosphate and megestrol acetate, both drugs used to treat prostate cancer, showed varying degrees of cellular atrophy and disorganization in the prostate of rats. The effects of estramustine phosphate resembled postcastration events, while megestrol acetate led to squamous metaplasia in some cases.
Paper Details　
Original Abstract of the Article :
The effects of estramustine phosphate on the ultrastructure of the rat ventral prostate closely resemble postcastration events, i.e., a decrease in cell size and secretory activities. The fibromuscular stroma, especially collagen fibers, appear to lose their adherence to adjoining muscle cells and f...See full text at original site
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引用元：
https://doi.org/10.1016/0090-4295(82)90609-4

データ提供：米国国立医学図書館（NLM）

Estramustine and Megestrol: Investigating their Impact on Prostate Cells

Prostate cancer is a prevalent health concern, and researchers are constantly exploring new treatment options. This study investigates the effects of two drugs, estramustine phosphate and megestrol acetate, on the ultrastructure of the rat ventral prostate. The study aimed to understand how these medications, often used in prostate cancer treatment, affect prostate cells at the microscopic level.

Estramustine: A Simulating Postcastration Effect

The study found that estramustine phosphate had a significant impact on prostate cells, mimicking the effects of castration. This observation highlights the potential of estramustine as a therapy for prostate cancer, potentially reducing prostate cell growth and activity. The researchers also observed an increase in cellular activity in the prostate of rats treated with megestrol acetate, suggesting a different mode of action for this drug.

Understanding Prostate Cell Dynamics

This study provides valuable insights into the complex interactions between prostate cells and these medications. It's like a microscopic journey through a desert landscape, revealing the intricate mechanisms by which these drugs affect prostate cell growth and function. While more research is needed to fully understand the long-term effects of these medications and their potential for treating prostate cancer, this study offers crucial information for guiding future research and clinical applications.

Dr.Camel's Conclusion

This research provides a glimpse into the intricate world of prostate cell dynamics, showcasing the potential impact of estramustine and megestrol acetate on prostate cell behavior. It's like uncovering a hidden oasis in the vast desert of prostate cancer research, offering clues to the mechanisms behind these medications' actions. While further research is needed to optimize their use and understand their full potential, this study serves as a reminder of the importance of understanding the cellular landscape in developing effective cancer therapies.

Date :
  1. Date Completed 1982-07-19
  2. Date Revised 2019-07-14
Further Info :

Pubmed ID

7080325

DOI: Digital Object Identifier

10.1016/0090-4295(82)90609-4

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Languages

English

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