Plasma fenfluramine levels, weight loss and side effects: a failure to find a relationship.

Author: BrownellK, CampbellD B, PietruskoR, StunkardA

Paper Details 
Original Abstract of the Article :
Thirty-six women were treated for 16 weeks with fenfluramine and behavior therapy. There was a strong correlation between drug dosage and plasma levels of fenfluramine. In contrast to two previous reports, however, there was no correlation between plasma levels of fenfluramine and its metabolite nor...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/7160955

データ提供:米国国立医学図書館(NLM)

Fenfluramine - A Weight Loss Drug with Uncertain Effects

This study investigates the relationship between fenfluramine levels, weight loss, and side effects in women undergoing treatment for obesity. The researchers found a strong correlation between drug dosage and plasma levels of fenfluramine. However, they failed to find a correlation between fenfluramine levels and weight loss or between these levels and side effects. This challenges previous findings and suggests that increasing drug levels to tolerance, a common practice at the time, may not be beneficial.

Fenfluramine - A Weight Loss Drug with Unclear Benefits

The study's findings raise questions about the effectiveness and safety of fenfluramine in achieving weight loss. The lack of correlation between drug levels and weight loss suggests that increasing dosage to achieve higher drug levels may not lead to greater weight loss. This highlights the need for further research to better understand the relationship between fenfluramine levels, weight loss, and side effects.

Fenfluramine - A Reminder for Cautious Prescription

This research underscores the importance of cautious prescription and careful monitoring of drug levels when using fenfluramine for weight loss. Think of fenfluramine as a desert oasis that may not always provide the expected refreshment. This study encourages a more nuanced approach to weight loss treatment, taking into account individual responses and potential risks.

Dr. Camel's Conclusion

This study adds another layer of complexity to the world of weight loss medications. The lack of correlation between fenfluramine levels and weight loss, coupled with the potential for side effects, raises concerns about the efficacy and safety of this drug. It highlights the need for a more personalized approach to weight loss treatment, considering individual responses and potential risks.

Date :
  1. Date Completed 1983-04-07
  2. Date Revised 2014-06-03
Further Info :

Pubmed ID

7160955

DOI: Digital Object Identifier

7160955

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PICO Info
in preparation
Languages

English

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