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Gastrointestinal therapeutic system for acetazolamide. Efficacy and side effects.
Author: BayneW, McGuireJ, TheeuwesF
Original Abstract of the Article :
Acetazolamide has been formulated in a new gastrointestinal therapeutic system that delivers the drug at an essentially constant rate of 15 mg/hr (GITS 15/125). We compared the therapeutic effect, magnitude of plasma concentration fluctuations, and incidence of side effects produced by the GITS 15/1...See full text at original site
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引用元:
https://doi.org/10.1001/archopht.1978.03910060521010
データ提供:米国国立医学図書館(NLM)
Acetazolamide: A New Delivery System for Glaucoma Treatment
Glaucoma, like a slow-moving desert sandstorm, can lead to vision loss if left untreated. This study focuses on a novel gastrointestinal therapeutic system (GITS) for delivering acetazolamide, a medication commonly used to manage glaucoma. The study compares the effectiveness of GITS 15/125 with conventional acetazolamide tablets, similar to contrasting different methods for transporting water through a desert. The GITS 15/125 delivered a steady release of acetazolamide, reducing the fluctuations in plasma concentration and, in turn, the incidence of side effects such as drowsiness and tingling sensations. This is like a consistent source of water in a desert, providing a steady supply without sudden bursts or shortages.
Improving Glaucoma Management
The GITS 15/125 demonstrated efficacy in reducing intraocular pressure, comparable to conventional tablets, but with fewer side effects. This is like finding a more efficient way to transport water, delivering the same results with less effort and fewer complications. The study highlights the importance of optimizing drug delivery systems for better therapeutic outcomes and patient well-being.
Living with Glaucoma: A Focus on Side Effects
Glaucoma patients may benefit from the reduced side effects associated with the GITS 15/125 delivery system. This is like finding a cooler oasis with more comfortable conditions for rest and rejuvenation. It's a reminder that even in the challenging landscape of chronic conditions, small improvements can make a big difference in a patient's quality of life. Regular eye checkups and discussions with healthcare providers are crucial for managing glaucoma effectively and preventing further vision loss.
Dr. Camel's Conclusion
This study showcases the power of innovation in drug delivery systems. The GITS 15/125 provides a more effective and comfortable way to manage glaucoma, making it an important tool for maintaining good vision and quality of life.
Date :
- Date Completed 1979-01-26
- Date Revised 2019-07-04
Further Info :
Related Literature
English
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