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[Fenofibrate: animal toxicology in relation to side-effects in man (author's transl)].

Author: BlaneG F, PinaroliF

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Chronic toxicity studies of fenofibrate were conducted in rats, dogs, and monkeys. No evidence of teratogenic effects, mutagenicity, or liver abnormalities was found in animals receiving doses up to 300 mg/kg/day. Side effects in clinical practice were rare and generally mild. Long-term clinical trials did not demonstrate any fenofibrate-induced pathology, suggesting that fenofibrate is a safe and effective drug.
Paper Details　
Original Abstract of the Article :
Chronic toxicity studies of fenofibrate were carried out in rats (3 months), dogs (7 et 24 months) and Rhesus monkeys (12 months). The results in the last named species (78 animals) were of particular interest, since the treated monkeys had normal size liver without histological abnormalities. Elect...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/7208340

データ提供：米国国立医学図書館（NLM）

Fenofibrate: A Look at its Effects and Side Effects

This study explores the [pharmacology and toxicology] of [fenofibrate], a medication used to lower [cholesterol] levels. The researchers conducted a series of studies in [animals] to assess the long-term effects of [fenofibrate]. They found that while [fenofibrate] was generally well-tolerated, some [side effects] were observed, such as [digestive disorders, sexual fatigue, myalgia, and alopecia]. The study also explored the potential for [fenofibrate] to cause [cancer or other health problems], but no evidence was found to support this.

Navigating the Side Effects of Medications

This study highlights the importance of being aware of the potential [side effects] of medications. While [fenofibrate] can be effective in lowering [cholesterol] levels, it's important to be aware of the possible risks and discuss any concerns with your healthcare provider. Open communication is crucial in making informed decisions about your health.

Balancing Benefits and Risks: A Collaborative Approach

This research reminds us that [medication management] is a collaborative process between patients and healthcare professionals. By discussing your [medical history, lifestyle, and concerns], you can work with your doctor to create a treatment plan that balances the benefits of medication with the potential risks.

Dr.Camel's Conclusion

This study is like a desert oasis that provides a safe haven for understanding the potential benefits and risks of [fenofibrate]. By knowing the lay of the land, we can navigate the journey of medication management with greater confidence and clarity.

Date :
  1. Date Completed 1981-05-13
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

7208340

DOI: Digital Object Identifier

7208340

Related Literature

Article Analysis
・Side Effects of fenofibrate
SNS
PICO Info
in preparation
Languages

French

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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