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The effect of quinidine and its metabolites on the electrocardiogram and systolic time intervals: concentration--effect relationships.

Author: CoatesP E, GuentertT W, HolfordN H, RiegelmanS, SheinerL B

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

A pharmacokinetic and pharmacodynamic model analyzed the effects of quinidine on electrocardiographic (ECG) and systolic time intervals (STI) in ten healthy subjects. Quinidine primarily affected cardiac repolarization, prolonging the QT interval. The pharmacodynamic model suggested the formation of pharmacologically active metabolites during absorption from the gut.
Paper Details　
Original Abstract of the Article :
1 A combined pharmacokinetic and pharmacodynamic model has been used to analyze the relationship between electrocardiographic (ECG) and systolic time intervals (STI) and changes in plasma concentration of quinidine after oral and i.v. doses in ten normal subjects. 2 The major effects of quinidine we...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2125.1981.tb01123.x

データ提供：米国国立医学図書館（NLM）

Quinidine and Its Metabolites: A Complex Dance in the Heart

Quinidine, a medication used to treat irregular heart rhythms, can have a significant impact on the heart's electrical activity. Imagine a delicate balance within the heart, like a calm oasis in the desert. This research delves into the effects of quinidine and its metabolites on the electrocardiogram (ECG), a test that measures the heart's electrical activity. It's like observing the intricate dance of the heart's electrical system, revealing how quinidine and its metabolites affect this delicate balance.

Understanding Quinidine's Effects: Navigating the Desert of Heart Rhythms

The researchers used a combined pharmacokinetic and pharmacodynamic model to analyze the relationship between quinidine's concentration in the blood and its effects on the ECG. This is like creating a map of the heart's electrical pathways, showing how quinidine and its metabolites travel and interact with the heart's rhythm. They found that quinidine mainly affects the heart's repolarization process, lengthening the QT interval, which reflects the time it takes for the heart to recharge after each beat. This finding is important because it highlights the potential for quinidine to cause dangerous heart rhythm abnormalities.

The Importance of Careful Monitoring: Ensuring a Safe Journey Through the Desert

This research emphasizes the importance of careful monitoring when prescribing quinidine. It's like having a vigilant guide to navigate the desert of potential heart rhythm issues. By closely monitoring the patient's ECG and blood levels of quinidine and its metabolites, healthcare providers can ensure that the medication is used safely and effectively, minimizing the risk of complications.

Dr. Camel's Conclusion

The desert of heart rhythms is a complex and delicate landscape. Quinidine, while helpful for treating arrhythmias, can also alter the heart's electrical activity. This research highlights the importance of understanding the effects of quinidine and its metabolites to ensure safe and effective treatment. By carefully navigating this terrain with monitoring and appropriate care, we can help patients achieve a balanced and healthy heart rhythm.

Date :
  1. Date Completed 1981-06-13
  2. Date Revised 2019-05-12
Further Info :

Pubmed ID

7213522

DOI: Digital Object Identifier

10.1111/j.1365-2125.1981.tb01123.x

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Languages

English

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