Comparison of amantadine and rimantadine for prevention of type A (Russian) influenza.

Author: CateT R, CouchR B, GoswickC B, QuarlesJ M

Paper Details 
Original Abstract of the Article :
The efficacies of 200 mg of daily doses of amantadine and of rimantadine for prevention of infection and illness due to influenza A/USSR/77 (H1N1) virus were compared in a double-blind, placebo-controlled study on a college campus. Frequencies of symptoms that might have been side effects of the dru...See full text at original site
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引用元:
https://doi.org/10.1016/0166-3542(81)90003-6

データ提供:米国国立医学図書館(NLM)

Amantadine vs. Rimantadine: A Comparative Study for Influenza Prevention

This study delves into the realm of [influenza prevention], comparing the effectiveness of two antiviral medications, [amantadine] and [rimantadine], in preventing [influenza A/USSR/77 (H1N1) virus] infection. The researchers conducted a double-blind, placebo-controlled trial on a college campus, evaluating the efficacy of these medications in reducing the incidence of [influenza] symptoms. The findings provide valuable insights into the relative efficacy of these medications in preventing [influenza A] infection.

Amantadine and Rimantadine: A Tale of Two Antivirals

The results indicated that [amantadine] was more effective in reducing the incidence of [seroconversions] and the severity of [influenza] symptoms in young adults compared to [rimantadine] and [placebo]. While [rimantadine] did not demonstrate a significant reduction in [seroconversions], it did lead to a significant reduction in the frequency and severity of [influenza] symptoms among those who did become infected. These findings suggest that both medications may have a role in preventing [influenza A] infection, but their effectiveness may vary depending on age and other factors.

Navigating the Desert of Influenza: Finding Protection Against the Virus

This research offers valuable insights into the use of [amantadine] and [rimantadine] for preventing [influenza A] infection, particularly in young adults. The findings highlight the potential for these medications to reduce the risk of infection and lessen the severity of symptoms. It's like finding a sturdy camel in a vast, unforgiving desert – a reliable companion for navigating the challenges of influenza season and finding protection against the virus.

Dr.Camel's Conclusion

This study provides valuable insights into the relative efficacy of amantadine and rimantadine in preventing influenza A infection. The findings suggest that amantadine may be more effective in reducing the incidence of seroconversions and the severity of influenza symptoms in young adults, while rimantadine can also contribute to a reduction in illness frequency and severity. These findings offer valuable guidance for clinicians seeking to optimize influenza prevention strategies, particularly for young adults.

Date :
  1. Date Completed 1982-05-12
  2. Date Revised 2019-09-20
Further Info :

Pubmed ID

7337431

DOI: Digital Object Identifier

10.1016/0166-3542(81)90003-6

Related Literature

SNS
PICO Info
in preparation
Languages

English

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