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[Comparison between the side-effects of fentanyl and morphine in conscious man (author's transl)].

Author: CathelinM, MalkiA, ViarsP, VignesR

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study compared the side-effects of fentanyl citrate and morphine chlorhydrate in patients with facial or trigeminal nerve pain. Both drugs showed similar sedation and frequency of vomiting, but fentanyl induced more euphoria and a more pronounced drop in ventilation than morphine. Importantly, morphine induced significant hypotension, while fentanyl had minimal cardiovascular effects.
Paper Details　
Original Abstract of the Article :
Fentanyl citrate or morphine chlorhydrate are injected intramuscularly at increasing doses to patients suffering from intense pain in the facial or trigeminal nerves territory: --fentanyl = 0.0015, 0.003, 0.006 mg/kg; --morphine = 0.100, 0.150, 0.200 mg/kg. The clinically observed side-effects are n...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/7457946

データ提供：米国国立医学図書館（NLM）

Comparing the Side-Effects of Fentanyl and Morphine

The field of [pain management] is constantly seeking safer and more effective pain relief options. This study explores the side effects of fentanyl and morphine, two commonly used analgesics, comparing their effects on patients experiencing intense facial pain. The authors meticulously analyze the observed side effects, providing valuable insights into the nuances of these powerful medications.

A Detailed Analysis of Analgesic Side Effects

This study found that both fentanyl and morphine induced similar drops in ventilation, but fentanyl's effect was more pronounced. Fentanyl also caused less vomiting, but more euphoria, than morphine. However, both medications led to similar levels of sedation. The study highlights a key difference in cardiovascular effects: morphine consistently induced dose-related hypotension, while fentanyl had negligible effects at equianalgesic doses. This is like comparing two camels traversing a sandy terrain – one camel may be faster, but the other may be more resistant to the heat. This study provides valuable insights for clinicians to make informed decisions about choosing the most appropriate analgesic for each individual patient.

Informed Choice for Pain Relief

This research provides clinicians with essential information to guide their choice of analgesic for patients experiencing intense pain. The study's findings underscore the importance of considering the individual patient's needs, potential side effects, and overall risk factors. It's like choosing the right camel for a specific journey – some camels may be better suited for long distances, while others may be better for navigating treacherous terrain. This study provides valuable insights into the unique characteristics of these medications, empowering clinicians to make informed choices for their patients.

Dr. Camel's Conclusion

This study contributes to our understanding of the nuanced side effects of fentanyl and morphine. The findings offer valuable insights for clinicians seeking to optimize pain relief for patients while minimizing potential risks. Like a skilled desert traveler, clinicians must be aware of the specific characteristics of each medication and choose the best option for each patient's needs.

Date :
  1. Date Completed 1981-03-27
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

7457946

DOI: Digital Object Identifier

7457946

SNS
PICO Info
in preparation
Languages

French

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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