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Cytotoxic and cytokinetic effects of 1-beta-D-arabinofuranosylcytosine, daunorubicin, and 6-thioguanine on HeLa cells in culture.

Author: ClarksonB D, DoblinJ M, FriedJ, PerezA G

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study investigated the interactions of 1-beta-D-arabinofuranosylcytosine, daunorubicin, and 6-thioguanine on the survival of HeLa cells. 1-beta-D-arabinofuranosylcytosine was found to protect cells against lethality induced by both 6-thioguanine and daunorubicin. The study suggests that 1-beta-D-arabinofuranosylcytosine can protect cells from the cytotoxic effects of other drugs, potentially by modulating DNA synthesis.
Paper Details　
Original Abstract of the Article :
Exponentially growing HeLa cells were exposed to 1-beta-D-arabinofuranosylcytosine, daunorubicin, and 6-thioguanine singly and in combination for 21 hr. Survivals were determined by a colony-counting assay, and cytokinetic effects of the drugs were evaluated by flow cytometry. When used in two-drug ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/7459856

データ提供：米国国立医学図書館（NLM）

Cytotoxic and Cytokinetic Effects of Anti-Cancer Drugs on HeLa Cells

This research examines the cytotoxic and cytokinetic effects of three anti-cancer drugs—1-beta-D-arabinofuranosylcytosine, daunorubicin, and 6-thioguanine—on HeLa cells in culture. The researchers investigated the effects of these drugs individually and in combination, assessing their impact on cell survival and cell cycle progression. They discovered that 1-beta-D-arabinofuranosylcytosine protected cells against the lethal effects of both 6-thioguanine and daunorubicin, highlighting a potential synergistic effect when used in combination.

Exploring Drug Interactions in Cancer Therapy

This research delves into the intricate world of drug interactions in cancer therapy. The researchers' findings provide valuable insights into the potential benefits and complexities of using multiple drugs in combination to combat cancer cells. Their observations about the protective effect of 1-beta-D-arabinofuranosylcytosine when combined with other drugs highlight the potential for synergistic therapies.

Implications for Cancer Treatment Strategies

The study's findings offer valuable insights into the mechanisms of action of anti-cancer drugs and their potential synergistic effects when used in combination. The research provides a foundation for developing more effective and targeted cancer treatment strategies. The researchers' observations about the protective effect of 1-beta-D-arabinofuranosylcytosine encourage further investigation into its potential role in combination therapies.

Dr. Camel's Conclusion

Think of these anti-cancer drugs as skilled desert warriors, fighting against the relentless advance of cancer cells. This research explores the power of strategic alliances, showing that when these warriors work together, they can achieve greater success in combatting the disease.

Date :
  1. Date Completed 1981-04-21
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

7459856

DOI: Digital Object Identifier

7459856

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Languages

English

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