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Comparison of the gonadotropin-releasing hormone agonist goserelin acetate alone versus goserelin combined with estrogen-progestogen add-back therapy in the treatment of endometriosis.

Author: HagmanE, KiilholmaP, KivinenS, KorhonenM, TuimalaR

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study aimed to determine if adding low-dose estrogen-progesterone hormone replacement therapy (HRT) to GnRH agonist (GnRH-a) treatment for endometriosis reduces side effects without impacting the effectiveness of the treatment. The study also investigated hormonal changes during treatment.
Paper Details　
Original Abstract of the Article :
To investigate whether the addition of low-dose estrogen-P combination hormone replacement therapy (HRT) to GnRH agonist (GnRH-a) treatment for endometriosis reduces the pharmacologic side effects of such treatment without reducing efficacy and to determine the endocrinologic changes during treatmen...See full text at original site
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引用元：
https://doi.org/10.1016/s0015-0282(16)57900-x

データ提供：米国国立医学図書館（NLM）

Endometriosis Treatment: Balancing GnRH Agonist and Estrogen

Endometriosis, a condition characterized by the growth of uterine lining tissue outside of the uterus, can cause debilitating pain and infertility. This study investigated the effectiveness of combining goserelin acetate, a gonadotropin-releasing hormone agonist (GnRH-a), with estrogen-progestogen add-back therapy in the treatment of endometriosis. The researchers aimed to determine if the addition of estrogen-progestogen would reduce the side effects associated with GnRH-a treatment without compromising its efficacy.

The Art of Balance: Balancing the Hormones in Endometriosis Treatment

This study explores the delicate balance of hormones in endometriosis treatment. The researchers investigated whether adding estrogen-progestogen to GnRH-a therapy could mitigate the side effects of GnRH-a alone while maintaining its therapeutic benefits.

Finding the Right Balance: Consulting with Your Healthcare Provider

This study highlights the importance of individualized treatment approaches for endometriosis. Working closely with your healthcare provider to find the right balance of medications and therapies is essential for managing the condition effectively and minimizing side effects.

Dr.Camel's Conclusion

This study reminds us that finding the right balance is key to treating endometriosis. It's like navigating a desert landscape - you need to find the right path that takes you to your destination without encountering too many obstacles.

Date :
  1. Date Completed 1995-12-07
  2. Date Revised 2019-07-07
Further Info :

Pubmed ID

7589632

DOI: Digital Object Identifier

10.1016/s0015-0282(16)57900-x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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