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Divergent effects of dihydropyridine and phenylalkylamine calcium channel antagonist classes on autonomic function in human hypertension.

Author: AdegbileI A, CervenkaJ H, KailasamM T, KennedyB P, O'ConnorD T, ParmerR J, WuR A, ZieglerM G

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study compared the acute and chronic effects of felodipine and verapamil on efferent sympathetic outflow and baroreflex slope in patients with essential hypertension. Felodipine produced a greater decrease in blood pressure and a larger decline in systemic vascular resistance than verapamil.
Paper Details　
Original Abstract of the Article :
Calcium channel antagonists differ by class in reported frequency of side effects that suggest reflex sympathoadrenal activation. Do such differences result from differential effects on autonomic and baroreflex function? The present study compared acute and chronic effects of two classes of calcium ...See full text at original site
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引用元：
https://doi.org/10.1161/01.hyp.26.1.143

データ提供：米国国立医学図書館（NLM）

Divergent effects of calcium channel antagonists

This research explores the fascinating world of calcium channel antagonists, medications used to treat high blood pressure. Imagine a desert where different types of cacti have unique ways of adapting to their environment. Similarly, different classes of calcium channel antagonists have varying effects on our bodies. The study investigates the distinct effects of two classes of calcium channel antagonists, dihydropyridine and phenylalkylamine, on autonomic function and baroreflex slope in hypertensive individuals.

Understanding Medication Effects

The study reveals significant differences in the effects of the two classes of calcium channel antagonists. While both types effectively lower blood pressure, they exert distinct influences on autonomic function, particularly sympathetic activity. This emphasizes the importance of considering the specific effects of different medications, even within the same class, to optimize treatment strategies.

Choosing the Right Medication

This research highlights the importance of choosing the right calcium channel antagonist based on individual needs and potential side effects. Understanding the different classes of these medications and their potential impact on autonomic function is crucial for healthcare professionals to personalize treatment strategies. This can help ensure patients receive the most effective and safe treatment possible.

Dr. Camel's Conclusion

This study is a reminder that the world of medicine is full of intricate complexities, like the intricate patterns of a desert sand dune. It emphasizes the importance of understanding the nuanced effects of different medications, even those within the same class. It's a reminder that we must carefully navigate the desert of pharmacological knowledge to ensure that our patients receive the most effective and safe treatment possible. By appreciating these complexities, we can better navigate the path to better health for all.

Date :
  1. Date Completed 1995-08-14
  2. Date Revised 2019-07-22
Further Info :

Pubmed ID

7607717

DOI: Digital Object Identifier

10.1161/01.hyp.26.1.143

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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