Effects of trifluoperazine on synaptically evoked potentials and membrane properties of CA1 pyramidal neurons of rat hippocampus in situ and in vitro.

Author: AgopyanN, KrnjevićK

Paper Details 
Original Abstract of the Article :
The effects of trifluoperazine (TFP), a phenothiazine antipsychotic, on hippocampal activity were studied in the CA1 subfield, both in situ and in slices. In the extracellular studies in situ and in vitro, both somatic population spikes and dendritic excitatory postsynaptic potentials (EPSP) fields ...See full text at original site
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引用元:
https://doi.org/10.1002/syn.890130103

データ提供:米国国立医学図書館(NLM)

Trifluoperazine: Exploring the Depths of Hippocampal Activity

The human brain is a complex and fascinating desert, with researchers continually exploring its intricate workings. This study investigates the effects of trifluoperazine (TFP), a phenothiazine antipsychotic, on the activity of CA1 pyramidal neurons in the hippocampus.

TFP: A Multifaceted Influence

The study reveals the multifaceted effects of TFP on hippocampal activity. The authors find that TFP can both depress and enhance synaptic transmission, demonstrating its complex and often paradoxical actions on neuronal function. It's like a desert wind that can both sculpt the dunes and carry seeds to new life.

Understanding the Brain's Landscape

This research highlights the need for a deeper understanding of the complex interactions between drugs and the brain. The authors emphasize the importance of considering the multiple mechanisms of action of drugs, as well as their effects on various neuronal pathways. Navigating the intricate landscape of the brain requires careful observation and a commitment to understanding its complexities.

Dr.Camel's Conclusion

This study explores the intricate relationship between drugs and the brain, reminding us of the vastness and complexity of the human nervous system. It's a reminder that even a seemingly simple drug can have profound and multifaceted effects, much like the intricate patterns of a desert landscape.

Date :
  1. Date Completed 1993-03-02
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

7678946

DOI: Digital Object Identifier

10.1002/syn.890130103

Related Literature

SNS
PICO Info
in preparation
Languages

English

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