Preclinical investigation of the antitumour effects of anti-CD19-idarubicin immunoconjugates.

Author: McKenzieI F, PieterszG A, RowlandA J

Paper Details 
Original Abstract of the Article :
Idarubicin (Ida), an analogue of daunomycin, was linked to a mouse monoclonal antibody against the B cell differentiation antigen CD19. Determination of the activity of both the antibody and drug moieties was carried out in vitro using a pre-B cell human acute lymphoblastic leukaemia cell line (NALM...See full text at original site
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引用元:
https://doi.org/10.1007/BF01525435

データ提供:米国国立医学図書館(NLM)

Targeting Cancer Cells: A New Approach with Immunoconjugates

Cancer is a complex and challenging disease to treat. This study explores a new approach using immunoconjugates, which are molecules that combine a targeting antibody with a chemotherapy drug. The researchers investigated the effectiveness of an anti-CD19-idarubicin immunoconjugate in treating a pre-B cell human acute lymphoblastic leukemia cell line. They found that the immunoconjugate effectively targeted and killed the cancer cells while minimizing toxicity to normal cells. In preclinical studies with mice bearing tumors, the immunoconjugate demonstrated significant antitumor activity, leading to complete tumor regression in some cases.

Precision Targeting: A Guided Journey to Cancer Eradication

The study's findings suggest that immunoconjugates could offer a more targeted and effective way to treat certain cancers. Think of it like a camel caravan crossing a vast desert; knowing the exact location of an oasis can make all the difference in survival. By targeting specific cancer cells, immunoconjugates can minimize damage to healthy tissues and potentially improve treatment outcomes.

Hope for Cancer Treatment: A New Frontier of Possibilities

This research represents a promising step forward in the fight against cancer. It's like a camel finding a hidden spring in the desert, a source of hope and renewal. By developing more targeted and effective therapies, we can bring hope and healing to patients battling cancer.

Dr. Camel's Conclusion

This study offers a compelling vision for the future of cancer treatment. It’s like a camel caravan discovering a new route through the desert, a path leading to a brighter horizon. Immunoconjugates represent a powerful new tool in our arsenal against cancer, offering hope for more effective and less toxic therapies.

Date :
  1. Date Completed 1993-08-24
  2. Date Revised 2019-09-09
Further Info :

Pubmed ID

7687521

DOI: Digital Object Identifier

10.1007/BF01525435

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Languages

English

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