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Long-term effects of transdermal and oral hormone replacement therapy on postmenopausal bone loss.

Author: ElleringtonM C, HillardT C, LeesB, MarshM S, StevensonJ C, WhitcroftS J, WhiteheadM I

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

In a study of 66 women who had recently gone through menopause, both transdermal and oral hormone replacement therapy (HRT) increased bone density over three years compared to women who did not receive HRT. Bone density decreased by 4% in the spine and more than 5% in the hip in the untreated group. Both types of HRT significantly reduced bone loss and slowed bone turnover. However, despite good adherence to treatment, 12% of women in both groups still experienced significant bone loss in the hip. Women using HRT primarily to prevent hip fractures may need to have their bone density checked regularly to ensure the treatment is effective.
Paper Details　
Original Abstract of the Article :
Transdermal hormone replacement therapy (HRT) is now an accepted form of treatment, but the long-term skeletal effects have not been assessed. Sixty-six early postmenopausal women were randomized to receive either transdermal HRT (continuous 17 beta-oestradiol 0.05 mg/day, with 0.25 mg/day of noreth...See full text at original site
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引用元：
https://doi.org/10.1007/BF01622195

データ提供：米国国立医学図書館（NLM）

Hormone Replacement Therapy: A Balancing Act for Bone Health

As a researcher, I've always been intrigued by the delicate balance within our bodies. It's like a complex desert ecosystem, where every element plays a crucial role in maintaining harmony. This study delves into the impact of hormone replacement therapy (HRT) on postmenopausal bone loss, a critical concern for women as they transition into a new stage of life. The researchers investigated the long-term skeletal effects of transdermal and oral HRT in a group of postmenopausal women, comparing their bone density and turnover with a control group.

HRT - A Potential Oasis for Bone Health

The study found that both transdermal and oral HRT effectively mitigated bone loss in postmenopausal women, demonstrating a significant increase in bone density compared to the control group. This is like a camel finding a refreshing oasis in the desert, helping to replenish and sustain its strength. The research suggests that HRT can play a role in maintaining bone health, particularly in women experiencing postmenopausal bone loss.

Maintaining Bone Health

This study highlights the importance of proactive strategies for maintaining bone health, particularly for postmenopausal women. While HRT can be an effective option, it's crucial to consult with a healthcare professional to determine the best approach based on individual needs and risks. A balanced diet rich in calcium and vitamin D, regular exercise, and healthy lifestyle choices can also contribute significantly to maintaining bone health.

Dr.Camel's Conclusion

This study, like a well-traveled camel caravan navigating a challenging terrain, explores the complex interplay between HRT and bone health. The research suggests that HRT can be a valuable tool for mitigating postmenopausal bone loss, but it emphasizes the need for a personalized approach based on individual factors and risks. Remember, maintaining bone health is an ongoing journey, and a combination of healthy lifestyle choices, medical interventions, and professional guidance can help us navigate this path effectively.

Date :
  1. Date Completed 1995-04-28
  2. Date Revised 2019-10-31
Further Info :

Pubmed ID

7696830

DOI: Digital Object Identifier

10.1007/BF01622195

SNS
PICO Info
in preparation
Languages

English

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