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Effectiveness of doxycycline combined with primaquine for malaria prophylaxis.

Author: BarnettA, EdsteinM D, RieckmannK H, ShanksG D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A daily regimen of doxycycline combined with low-dose primaquine was not effective in preventing malaria in Australian Defence Force personnel deployed to Papua New Guinea. While doxycycline appears effective in suppressing malaria while the drug is being taken, it cannot be relied on for causal prophylaxis.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To assess the causal prophylactic activity (activity against the pre-erythrocytic liver stage) of a daily regimen of doxycycline combined with low dose primaquine against malaria in Australian Defence Force personnel deployed to Papua New Guinea (PNG). PARTICIPANTS AND SETTING: A 53-stro...See full text at original site
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引用元：
https://doi.org/10.5694/j.1326-5377.1995.tb139906.x

データ提供：米国国立医学図書館（NLM）

Malaria Prophylaxis: A Complex Challenge for Travelers

Malaria is a serious mosquito-borne disease that can be life-threatening. Effective prophylaxis is crucial for travelers visiting malaria-endemic regions. This study investigated the efficacy of a combination drug regimen—doxycycline and primaquine—for malaria prophylaxis in Australian military personnel deployed to Papua New Guinea.

A Sandstorm of Challenges: The Complexities of Malaria Prevention

The study found that while the combination of doxycycline and primaquine was effective in preventing malaria during the deployment period, it did not provide complete protection against malaria after returning to Australia. This finding underscores the complexities of malaria prophylaxis, emphasizing the need for comprehensive strategies that include preventative measures, continued monitoring, and prompt treatment if infection occurs. This situation is like navigating a desert with unpredictable sandstorms—sometimes, even with the best precautions, you may encounter unforeseen challenges.

Protecting Yourself: Understanding the Risks and Taking Action

For travelers planning to visit malaria-endemic regions, it's essential to consult with a healthcare professional to understand the risks and to develop a personalized malaria prevention plan. This may include taking prophylactic medication, using mosquito repellents, and wearing protective clothing.

Dr. Camel's Conclusion

This research highlights the complexities of malaria prophylaxis, illustrating the need for comprehensive strategies to effectively prevent this dangerous disease. It's like navigating a vast desert—understanding the risks and taking precautions can help minimize the danger and ensure a safe and enjoyable journey.
Date :
  1. Date Completed 1995-05-18
  2. Date Revised 2020-12-19
Further Info :

Pubmed ID

7715493

DOI: Digital Object Identifier

10.5694/j.1326-5377.1995.tb139906.x

Related Literature

Article Analysis
・Side Effects of primaquine
SNS
PICO Info
in preparation
Languages

English

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