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Effects of two formats of informed consent on knowledge amongst persons with advanced HIV disease in a clinical trial of didanosine.

Author: BarkerS, CooperD A, FordeS, GoldsteinD, RossM W, TindallB

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Most subjects obtain information about HIV-related issues from their healthcare providers. Subjects generally believe their healthcare providers act in their best interests and should be allowed to choose between participating in a clinical trial or receiving medication outside of a trial. Providing information in both written and verbal formats can significantly improve knowledge levels about clinical trials.
Paper Details　
Original Abstract of the Article :
To determine subjects' perception of the purpose of informed consent, 113 subjects were recruited from a dose-controlled clinical trial of didanosine (ddI). Subjects were surveyed regarding how they made decisions regarding their medical care in general, about how they obtained information about thi...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1016/0738-3991(94)90069-8

データ提供：米国国立医学図書館（NLM）

Informed Consent and Knowledge: A Crucial Step in HIV Clinical Trials

Informed consent is a fundamental principle in research, ensuring that participants understand the risks and benefits of their involvement. This study examines the effects of different informed consent formats on knowledge levels among individuals with advanced HIV disease participating in a clinical trial of didanosine (ddI).

Knowledge is Power: Exploring Different Informed Consent Methods

The researchers compared the effectiveness of written-only informed consent with a combined written and verbal format. They found that both formats were associated with significant increases in knowledge about ddI, but the written plus verbal method led to greater improvements. This highlights the importance of providing clear and comprehensive information to research participants to ensure their understanding of the trial.

Navigating the Desert of Information: The Importance of Clear Communication

This study underscores the importance of clear communication and education in research. Just as a camel caravan needs a skilled guide to navigate the desert, so too do research participants need clear and concise information to understand the complexities of clinical trials. The findings emphasize the need for multimodal approaches to informed consent, ensuring that participants fully understand the nature of their involvement in research.

Dr.Camel's Conclusion

This research emphasizes the power of knowledge in research. By providing clear and comprehensive information to participants, we can empower them to make informed decisions about their involvement in clinical trials and contribute to the advancement of scientific knowledge.

Date :
  1. Date Completed 1995-06-22
  2. Date Revised 2019-09-20
Further Info :

Pubmed ID

7753719

DOI: Digital Object Identifier

10.1016/0738-3991(94)90069-8

Related Literature

Article Analysis
・Effects of didanosine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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