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In vivo measurement of tumor blood oxygenation by near-infrared spectroscopy: immediate effects of pentobarbital overdose or carmustine treatment.

Author: KitagishiK, MorganK, SteenR G

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Near-infrared spectroscopy shows that tumor tissue consumes significantly less oxygen than brain tissue during pentobarbital overdose. Carmustine treatment can potentially increase tumor blood oxygenation.
Paper Details　
Original Abstract of the Article :
Near-infrared (NIR) spectroscopy was used to measure blood oxygen saturation (SO2) in vivo, in normal rat brain and in subcutaneously-implanted rat 9L gliosarcoma. Changes in cranial and tumor blood SO2 were measured during lethal pentobarbital overdose. After sacrifice, SO2 of cranial blood fell ra...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1007/BF01052921

データ提供：米国国立医学図書館（NLM）

Blood Oxygenation in Tumors

This study explores the intriguing world of tumor biology, focusing on blood oxygenation levels in tumor tissue. It utilizes near-infrared (NIR) spectroscopy, a technique that allows researchers to measure oxygen saturation levels in living tissues. The researchers observed that tumor tissue, much like a desert oasis in the scorching sun, has a lower oxygen consumption rate than normal brain tissue. Furthermore, they found that a certain chemotherapy drug, carmustine (BCNU), can potentially increase oxygen levels in tumor tissue.

Potential for New Treatments

This study opens doors for potential new treatment strategies. Understanding how oxygen levels in tumor tissue behave could lead to the development of more effective and targeted therapies.

Understanding Cancer Better

This study is a testament to our ongoing efforts to understand cancer better. By studying the inner workings of tumors, we can unlock secrets that will pave the way for more effective treatment options in the future.

Dr.Camel's Conclusion

This study sheds light on the complexities of tumor biology and the potential for new treatment strategies targeting tumor oxygenation. It is a reminder that even in the vast expanse of medical unknowns, we can make strides towards a brighter future.

Date :
  1. Date Completed 1995-06-26
  2. Date Revised 2019-09-09
Further Info :

Pubmed ID

7760097

DOI: Digital Object Identifier

10.1007/BF01052921

Related Literature

Article Analysis
・Effects of carmustine
SNS
PICO Info
in preparation
Languages

English

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