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Bronchodilatory and circulatory effects of two doses of a beta2-agonist (terbutaline) inhaled with IPPB in patients with reversible airways obstruction.

Author: SimonssonB G, StrömB, SvedenbladH

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Inhaled terbutaline (2.5 and 5 mg) effectively improved peak expiratory flow rate (PEFR) and forced expiratory volume in one second (FEV1) in patients with asthma. Higher doses resulted in greater and longer-lasting effects. While some patients experienced tremor and palpitations, terbutaline generally had minimal systemic effects on heart rate and tremor.
Paper Details　
Original Abstract of the Article :
A beta2-receptor agonist, terbutaline (Bricanyl), in doses of 2.5 and 5 mg was inhaled by IPPB with a Bird Mark 8 in a double-blind cross-over randomized study on consecutive days in 12 patients with at least 15% reversibility of PEFR or FEV 1.0. One minute after the inhalation of 2.5 mg, PEFR had i...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/792994

データ提供：米国国立医学図書館（NLM）

Exploring the Bronchodilatory and Circulatory Effects of Terbutaline: A Double-Blind, Crossover Study

Reversible airways obstruction, a common respiratory condition, is often managed with inhaled bronchodilators. This study investigates the bronchodilatory and circulatory effects of terbutaline, a beta2-receptor agonist, when inhaled using intermittent positive pressure breathing (IPPB) in patients with reversible airways obstruction. The authors conducted a double-blind, crossover study to compare the effects of two different terbutaline doses on lung function and heart rate.

Terbutaline: A Promising Bronchodilator with Minimal Systemic Effects

The study demonstrates that terbutaline effectively dilates the airways, improving lung function in patients with reversible airways obstruction. It also reveals that terbutaline has minimal systemic effects on heart rate, suggesting that it may be a safer option for patients who are concerned about cardiovascular side effects. This research provides valuable insights into the bronchodilatory and circulatory properties of terbutaline, informing its use in the management of reversible airways obstruction.

Optimizing Respiratory Health: Tailoring Treatment to Individual Needs

This study underscores the importance of tailoring treatment to the individual needs of patients with respiratory conditions. It highlights the need for careful consideration of potential side effects and the importance of monitoring heart rate and other vital signs when using inhaled bronchodilators. This research contributes to a more nuanced understanding of the effects of terbutaline, guiding clinicians in making informed treatment decisions.

Dr.Camel's Conclusion

Just as a camel navigates the shifting sands of a desert, finding the most effective path to its destination, patients with respiratory conditions require individualized treatment approaches. This study provides valuable insights into the bronchodilatory and circulatory effects of terbutaline, reminding us that careful consideration of potential side effects and personalized treatment plans are crucial for optimizing respiratory health.

Date :
  1. Date Completed 1977-01-25
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

792994

DOI: Digital Object Identifier

792994

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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