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Ascorbic acid (vitamin C) modulates the mutagenic effects produced by an alkylating agent in vivo.

Author: AidooA, LensingS, Lyn-CookL E, WamerW

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Ascorbic acid (vitamin C) was found to have antimutagenic effects in vivo, significantly reducing the mutagenicity of N-ethyl-N-nitrosourea (ENU), a direct-acting mutagen/carcinogen, in Fischer 344 rats.
Paper Details　
Original Abstract of the Article :
Recent reports suggest that ascorbic acid (vitamin C) inhibits tumorigenesis as well as exerts a protective effect against mutagenesis in vitro; however, there is no information on its ability to affect gene mutations induced in vivo. In this study, we have investigated the antimutagenic effects of ...See full text at original site
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引用元：
https://doi.org/10.1002/em.2850240311

データ提供：米国国立医学図書館（NLM）

Vitamin C: A Powerful Antioxidant with Anti-Mutagenic Potential

Ascorbic acid (vitamin C) is a well-known antioxidant. This study investigated the antimutagenic effects of vitamin C against the mutagenic effects of N-ethyl-N-nitrosourea (ENU), a direct-acting alkylating agent, in rats. The study found that pretreatment and post-treatment with vitamin C significantly reduced the frequency of 6-thioguanine-resistant (6-TGr) T-lymphocytes, a marker of mutagenicity, in rats treated with ENU. The study concluded that vitamin C intake affects the in vivo mutagenicity of ENU, suggesting that its reported inhibitory effects on carcinogenesis may be mediated by its effects on mutagenesis.

Vitamin C: A Powerful Antioxidant with Anti-Mutagenic Potential

This study provides evidence for the antimutagenic properties of vitamin C. The researchers found that vitamin C can effectively reduce the mutagenic effects of ENU in rats. This research highlights the potential of vitamin C as a protective agent against the mutagenic effects of environmental toxins.

A Hidden Oasis of Antimutagenic Benefits

This study provides a compelling reason to include vitamin C in our diet. The researchers found that vitamin C can offer protection against the mutagenic effects of environmental toxins. It's like discovering a hidden oasis of antimutagenic benefits in the vast desert of dietary choices.

Dr. Camel's Conclusion

This study highlights the antimutagenic properties of vitamin C. It's like finding a refreshing oasis in the desert of nutritional research. This research underscores the importance of incorporating vitamin C into our diets for maintaining health and preventing the harmful effects of environmental toxins.

Date :
  1. Date Completed 1994-12-12
  2. Date Revised 2019-10-23
Further Info :

Pubmed ID

7957125

DOI: Digital Object Identifier

10.1002/em.2850240311

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・Effects of ascorbic acid (vitamin c)
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PICO Info
in preparation
Languages

English

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