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Selective antimitotic effects of estramustine correlate with its antimicrotubule properties on glioblastoma and astrocytes.
Author: Cornell-BellA, PiepmeierJ M, YoshidaD
Original Abstract of the Article :
Estramustine is an estradiol-based agent that accumulates in cells containing estramustine binding protein. Previous studies have shown that this binding site is expressed in human glioblastoma cells and that estramustine accumulates in glioma cells, resulting in a concentration-dependent inhibition...See full text at original site
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引用元:
https://doi.org/10.1227/00006123-199405000-00012
データ提供:米国国立医学図書館(NLM)
Selective Antimitotic Effects of Estramustine Correlate with Its Antimictrotubule Properties on Glioblastoma and Astrocytes
This research explores the effects of estramustine, a drug used to treat prostate cancer, on glioblastoma (a type of brain cancer) and astrocytes (a type of brain cell). It’s like studying the impact of a specific desert herb on different types of desert organisms. The study aims to understand how estramustine, like a targeted desert remedy, selectively inhibits the growth of glioblastoma cells.Selective Antimitotic Effects
The study found that estramustine, like a precise desert insecticide, effectively inhibits the growth of glioblastoma cells while having minimal effects on astrocytes. The researchers discovered that estramustine's antimitotic effects, which inhibit cell division, are closely linked to its ability to disrupt microtubules, crucial structures within cells. This research provides valuable insights into the potential of estramustine as a treatment for glioblastoma, like discovering a valuable medicinal plant in the desert.A Targeted Approach to Cancer Treatment
This research offers hope for the development of more targeted therapies for glioblastoma, like a carefully crafted irrigation system for a desert oasis. The study suggests that estramustine, by disrupting microtubules specifically in glioblastoma cells, could be a valuable tool for selectively targeting cancer cells while minimizing damage to healthy cells. This could lead to the development of more effective and less toxic treatments for this aggressive cancer.Dr.Camel's Conclusion
This research, like a journey through a diverse desert ecosystem, reveals the selective antimitotic effects of estramustine on glioblastoma and astrocytes. The study suggests that estramustine, by disrupting microtubules specifically in glioblastoma cells, could be a valuable tool for selectively targeting cancer cells while minimizing damage to healthy cells. This research offers hope for the development of more targeted and effective therapies for glioblastoma, providing a beacon of hope for patients battling this challenging disease.Date :
- Date Completed 1994-09-08
- Date Revised 2019-05-12
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