In vitro effects of artemisinin ether, cycloguanil hydrochloride (alone and in combination with sulfadiazine), quinine sulfate, mefloquine, primaquine phosphate, trifluoperazine hydrochloride, and verapamil on Toxoplasma gondii.

Author: HolfelsE, MackD, McAuleyJ, McLeodR, MilhousW K

Paper Details 
Original Abstract of the Article :
The in vitro effect of the following antimicrobial agents on Toxoplasma gondii tachyzoites were studied: artemisinin ether (arteether), cycloguanil hydrochloride (cycloguanil), mefloquine, primaquine phosphate, and quinine sulfate, as well as the calcium channel blocker verapamil and the calmodulin ...See full text at original site
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引用元:
https://doi.org/10.1128/AAC.38.6.1392

データ提供:米国国立医学図書館(NLM)

Combatting Toxoplasma: A Battle in the Desert

Imagine a harsh desert environment, where microscopic parasites like Toxoplasma gondii can thrive, posing a threat to human health. This research explores the effectiveness of various antimicrobial agents against T. gondii, seeking to find weapons to combat this parasitic threat. The researchers meticulously tested a range of compounds, evaluating their efficacy in inhibiting the growth of T. gondii in laboratory settings.

A Search for Solutions: Identifying Effective Antimicrobials

The research revealed that arteether and cycloguanil hydrochloride exhibited inhibitory effects on T. gondii, offering potential therapeutic options for tackling this parasitic infection. It's like discovering hidden weapons in the desert, capable of combating the threats lurking within. The researchers also found that combining cycloguanil with sulfadiazine enhanced its efficacy, suggesting that synergistic approaches could be crucial for overcoming this parasite.

A Journey Towards Prevention: Understanding the Threat

This research underscores the importance of understanding the mechanisms of parasitic infections and developing effective treatments to protect human health. It's like navigating a treacherous desert, where knowledge and preparedness are essential for survival. The researchers' findings provide valuable insight into the fight against T. gondii, guiding scientists and clinicians in their efforts to develop new therapeutic strategies and prevent the spread of this parasite.

Dr.Camel's Conclusion

This research highlights the importance of ongoing research and development in the field of antimicrobial drug discovery. It's like exploring a vast desert, where each new finding reveals a hidden pathway towards combating infectious diseases. The researchers' findings provide valuable insight into the fight against T. gondii, offering a beacon of hope for a future where we can effectively protect ourselves from this parasitic threat.

Date :
  1. Date Completed 1994-10-17
  2. Date Revised 2021-09-15
Further Info :

Pubmed ID

8092843

DOI: Digital Object Identifier

10.1128/AAC.38.6.1392

SNS
PICO Info
in preparation
Languages

English

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