Paper Details

  1. Home
  2. Paper Details

Continuous progesterone exposure associated with high contraction frequency in human term myometrial strips.

Author: BäckströmT, LöfgrenM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Progesterone was found to delay the onset of contractions in human myometrial strips continuously exposed to the hormone. Once contractions began, progesterone significantly increased contraction frequency compared to control groups and those treated with progesterone metabolites. This suggests that continuous progesterone exposure might facilitate myometrial contraction frequency during labor.
Paper Details　
Original Abstract of the Article :
It has been shown that progesterone slightly reduced the work of human term myometrial strips. In vitro, 5 alpha-pregnane-3,20-dione and 3 alpha-hydroxy-5 alpha-pregnan-20-one, two major extra-hepatic metabolites of progesterone, had only minor effects or none at all. The myometrial strips were stor...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.3109/00016349409023436

データ提供：米国国立医学図書館（NLM）

Progesterone's Impact on Uterine Contractions: A New Perspective

The role of [progesterone] in [labor and delivery] has been a topic of ongoing research. This study examines the effect of continuous progesterone exposure on the contractile activity of [human term myometrial strips].

Progesterone: A Complex Role in Contractions

The study found that continuous exposure to progesterone delayed the onset of contractions in myometrial strips, which is consistent with the general understanding of progesterone's role in suppressing labor. However, once contractions began, the frequency of contractions was significantly higher in the progesterone-superfused strips compared to controls. This unexpected finding suggests that continuous progesterone exposure may facilitate contraction frequency once labor is initiated.

Implications for Understanding Labor

This research challenges the traditional view of progesterone solely as an inhibitor of labor. The findings suggest that progesterone may have a more complex role in regulating uterine contractions, potentially acting as a facilitator of contraction frequency during labor. Further research is needed to fully understand the mechanisms underlying this effect and its implications for pregnancy and delivery.

Dr.Camel's Conclusion

The journey of labor is as unpredictable as a desert sandstorm: it might seem calm one moment and then erupt with intensity the next. This research delves into the complex role of progesterone, a vital hormone in the process of labor, highlighting its intricate dance between suppression and facilitation of uterine contractions. It's like discovering a hidden oasis in the desert, where a seemingly calming element can also fuel the unexpected bursts of energy needed for a journey to completion.

Date :
  1. Date Completed 1994-04-05
  2. Date Revised 2019-08-15
Further Info :

Pubmed ID

8122496

DOI: Digital Object Identifier

10.3109/00016349409023436

Related Literature

Article Analysis
・Effects of progesterone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.