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Effects of oophorectomy and hormone replacement therapy on plasma lipids.

Author: CasalsE, Castelo-BrancoC, González-MerloJ, IglesiasX, SanllehyC

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

In a study of 90 women, the effects of oophorectomy (surgical removal of the ovaries) and different hormone replacement therapies (HRT) on blood lipids were investigated. Women who had their ovaries removed had increased levels of LDL cholesterol (bad cholesterol) and decreased levels of HDL cholesterol (good cholesterol). All types of HRT tested (oral and transdermal estrogen with or without continuous progesterone) reversed these changes, resulting in lower LDL cholesterol and higher HDL cholesterol. While there were no significant changes in total cholesterol, women taking transdermal estrogen had lower triglycerides.
Paper Details　
Original Abstract of the Article :
The aim of this study was to determine the effects on plasma lipids and lipoproteins of oophorectomy and various hormone replacement therapy (HRT) delivery systems using low doses of medroxyprogesterone acetate (MPA, 2.5 mg/day). A total of 90 women completed the 1-year follow-up period. Patients we...See full text at original site
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引用元：
https://doi.org/10.1016/0378-5122(93)90006-4

データ提供：米国国立医学図書館（NLM）

The Shifting Sands of Hormones: Navigating the Landscape of Oophorectomy and Hormone Replacement Therapy

The human body, like a complex desert ecosystem, is influenced by a delicate balance of hormones. This study investigates the effects of oophorectomy, the surgical removal of ovaries, and hormone replacement therapy (HRT) on plasma lipid levels. The researchers conducted a study to examine the impact of different HRT regimens on lipid profiles, akin to a desert explorer studying the effects of water sources on the diverse flora and fauna of a desert ecosystem.

A Journey Through the Hormonal Desert: Examining the Effects of Oophorectomy and HRT

This study highlights the significant impact of oophorectomy on lipid levels, leading to increases in low-density lipoprotein (LDL), a key contributor to cardiovascular disease. However, the study also shows that HRT can effectively mitigate these changes, reducing LDL levels and increasing high-density lipoprotein (HDL), known for its protective effect on the heart.

A Guide to Hormonal Health: Navigating the Landscape of Women's Health

This study provides valuable insights into the impact of oophorectomy and HRT on lipid profiles, offering guidance for physicians and patients navigating the complex landscape of women's health. The findings underscore the importance of personalized treatment plans and careful monitoring to optimize lipid levels and maintain cardiovascular health.

Dr. Camel’s Conclusion

This study underscores the importance of understanding the delicate balance of hormones in the human body. It reveals the significant impact of oophorectomy on lipid levels, a key factor in cardiovascular health. However, the study also highlights the potential of HRT to mitigate these changes, providing a valuable tool for managing lipid profiles and promoting overall health. This research is a reminder of the complex interplay between hormones and health, emphasizing the need for personalized approaches to healthcare.

Date :
  1. Date Completed 1993-12-14
  2. Date Revised 2019-09-14
Further Info :

Pubmed ID

8231903

DOI: Digital Object Identifier

10.1016/0378-5122(93)90006-4

SNS
PICO Info
in preparation
Languages

English

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