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Omeprazole ameliorates aspirin-induced gastroduodenal injury.

Author: BehlerE M, EltaG H, LoefflerK M, ScheimanJ M

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Omeprazole effectively prevented gastroduodenal injury caused by aspirin in healthy volunteers. It significantly decreased aspirin-induced gastric mucosal injury and protected 85% of subjects from extensive erosions or ulceration. No subject taking omeprazole developed duodenal injury.
Paper Details　
Original Abstract of the Article :
Aspirin and nonsteroidal antiinflammatory drugs (NSAIDs) damage the gastroduodenal epithelium by two mechanisms: direct toxic effects and effects related to the depletion of endogenous prostaglandins. The prostaglandin-depleted mucosa has increased susceptibility to luminal aggressive factors, yet t...See full text at original site
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引用元：
https://doi.org/10.1007/BF02090067

データ提供：米国国立医学図書館（NLM）

Omeprazole: A Protective Shield Against Aspirin-Induced Gastroduodenal Injury

Aspirin, a common pain reliever, can cause damage to the stomach lining, a condition known as gastroduodenal injury. It's like a scorching desert sun that can burn and irritate the delicate skin of a traveler. This study explores the protective effects of omeprazole, a proton pump inhibitor, against aspirin-induced injury.

The researchers conducted a double-blind, placebo-controlled, crossover study involving healthy volunteers. They found that omeprazole significantly reduced aspirin-induced gastric mucosal injury, protecting the stomach lining from damage. This is like providing a caravan with a protective shield against the harsh desert sun, ensuring their safety and well-being.

Protecting the Digestive System: A Vital Role for Omeprazole

This study highlights the importance of omeprazole in preventing aspirin-induced gastroduodenal injury. It suggests that omeprazole could be a valuable tool for protecting the digestive system, especially in individuals who need to take aspirin for medical reasons.

Dr. Camel's Conclusion

This study is like a camel caravan discovering a hidden oasis of protection in the desert of aspirin-induced gastroduodenal injury. It reveals the potential of omeprazole to shield the digestive system from damage, offering a safe passage through the harsh terrain of aspirin use.

Date :
  1. Date Completed 1994-02-17
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

8281875

DOI: Digital Object Identifier

10.1007/BF02090067

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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