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A controlled comparison of the effects of propranolol, benztropine, and placebo on akathisia: an interim analysis.

Author: AdlerL A, AngristB, PeselowE, RosenthalM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

Propranolol and benztropine were effective in treating akathisia, showing significant improvement by day 3-5 of treatment. Placebo had no effect on akathisia. Benztropine caused confusion or forgetfulness in 3 patients, which resolved upon discontinuation.
Paper Details　
Original Abstract of the Article :
A group of 28 patients was treated to compare the effects on akathisia of the following: propranolol (80 mg/day), benztropine (6 mg/day), or placebo. Both propranolol and benztropine significantly improved akathisia by Day 3-5 of treatment. Placebo had no significant effects of akathisia. Three pati...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/8290678

データ提供：米国国立医学図書館（NLM）

Easing the Discomfort of Akathisia: Exploring New Treatment Options

Akathisia, a distressing neurological condition characterized by restlessness and an inability to sit still, can be like a relentless desert wind, driving a person to move constantly. This study explores the effectiveness of two medications, propranolol and benztropine, in treating akathisia.

Researchers compared the effects of propranolol, benztropine, and placebo on akathisia in a group of 28 patients. Both propranolol and benztropine significantly improved akathisia within a few days of treatment, while placebo had no effect. While both medications showed positive results, benztropine was associated with potential side effects like confusion or forgetfulness.

Finding Relief from Akathisia: A Potential New Path

This study sheds light on the potential benefits of propranolol and benztropine in treating akathisia. While further research is needed to optimize treatment strategies and explore long-term outcomes, these findings provide a promising avenue for managing this challenging condition.

Navigating the Desert of Akathisia: Understanding Treatment Options and Side Effects

For individuals experiencing akathisia, it is important to discuss treatment options with a healthcare professional. This study highlights the potential benefits of propranolol and benztropine, while also emphasizing the need for careful monitoring for potential side effects.

Dr. Camel's Conclusion

This research, like a soothing oasis in the desert of akathisia, offers potential relief for individuals struggling with this restless condition. While further research is needed to understand the long-term benefits and risks of these medications, they represent a promising avenue for managing this challenging neurological condition.

Date :
  1. Date Completed 1994-02-23
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

8290678

DOI: Digital Object Identifier

8290678

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・Effects of benztropine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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